About this Research Topic
The goal of the current Research Topic is to focus on (1) ICIs and immunometabolism in the context of the TIME and cancer immunotherapies and (2) The betterment of existing ICIs via IR in terms of efficacy and decreasing their immune and endocrine toxicities. This Research Topic is designed to attract oncologists and cancer immunologists who work with ICIs and cancer immunology. Immunometabolism is relatively new to oncologists, cancer biologists, and immunologists. However, cancer cell metabolism is known to cancer biologists for 100 years as Otto Warburg described increased aerobic glycolysis in them. The shift from OXPHOS to aerobic glycolysis is known as Warburg effect. Thus, this Research Topic will focus on cancer and immune cell-specific metabolic reprograming and their impact on different immune checkpoints, such PD-1, PD-L1, LAG3, TIM-3, CECAM-1, BTLA, and CTLA-4 expression and functioning.
This Research Topic welcomes Commentaries, Original Research and Review articles, and Perspective and Opinion articles. It aims to cover, but is not limited to, the following subtopics:
• Status of ICIs in cancer immunotherapy
• Cancer cell metabolism and immune checkpoint expression, regulation, and activity
• Immunometabolic reprograming in cancer or tumor immune microenvironment (TIME)
• Effect of immunometabolic reprograming and immune checkpoints
• Targeting immunometabolic reprograming to increase the efficacies of current immune checkpoint inhibitors
Note that John Stewart IV sits in the scientific Advisory Board of AmmunBio. Additionally, please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Cancer; Cancer cell metabolism; Immunometabolism; Immune checkpoints; Immune checkpoint inhibitors; Tumor immune microenvironment (TIME)
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.