Microbiota-Immunity Dynamics in Cancer: Mechanisms and Implications for Treatment Strategies

Cancer research is increasingly focusing on the intricate relationship between the host microbiota and the immune system, recognizing it as a significant factor influencing cancer progression and treatment responses. Recent studies have highlighted the role of intratumoral microbiota in modulating key processes such as immune evasion, genomic instability, and metabolic regulation, all of which contribute to tumorigenesis. Despite these advances, there remain critical gaps in understanding the precise mechanisms through which microbiota influences cancer dynamics. Current debates center around the potential of targeting microbiota to enhance the efficacy of cancer therapies, including immunotherapy and chemotherapy. While some studies have demonstrated promising results, the field still lacks comprehensive insights into the complex interactions between microbiota and the immune system within the tumor microenvironment. Addressing these gaps is essential for advancing precision medicine strategies that can effectively combat cancer by modulating the tumor microenvironment.

This research topic aims to explore the dynamic relationship between microbiota and immunity in cancer, focusing on the mechanisms by which microbiota influences cancer progression and treatment outcomes. The objective is to gather cutting-edge research that elucidates the implications of intratumoral microbiota for various cancer therapies, including immunotherapy, chemotherapy, and engineered microbial interventions. By doing so, the research seeks to enhance therapeutic efficacy and contribute to the development of precision cancer treatments.

To gather further insights in the dynamic interplay between microbiota and immunity in cancer, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms by which intratumoral microbiota modulates immune response and promotes immune evasion.
- The role of specific microbial species in enhancing or diminishing the efficacy of immunotherapy and chemotherapy.
- Insights into microbial-driven immunity dynamics and their impact on cancer progression.
- The role of gut-tumor microbiome crosstalk in influencing cancer treatment outcomes and potential intervention points for precision medicine.
- Comparative analyses of intratumoral versus gut microbiota in shaping tumor biology and treatment resistance.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.