The JAK/STAT signaling pathway is pivotal in organ development, governing key cellular processes like proliferation, differentiation, and survival. It responds to a spectrum of cytokines and growth factors, crucial for immune response, tissue differentiation, and organ function, including mammary glands and liver. Dysregulation of this pathway, characterized by aberrant JAK/STAT transduction, can have far-reaching consequences. It triggers proinflammatory cytokine signaling, disrupting immune homeostasis and fostering the development of autoimmune diseases. Additionally, dysregulation of the JAK/STAT pathway is implicated in various metabolic disturbances such as fatty liver, diabetes, and contributes to the development of cancer. Therefore, maintaining the proper functioning of the JAK/STAT pathway is essential for overall organ health and systemic homeostasis.
Variations within JAK/STAT genes can alter the function of critical components like JAKs and STATs, impacting immune responses and predisposing individuals to autoimmune conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, as well as certain cancers. Moreover, these genetic variations influence responses to drugs targeting the JAK/STAT pathway, affecting treatment efficacy and side effects. Consequently, deciphering these genetic nuances holds promise for personalized medicine, enabling tailored treatments aligned with an individual's genetic makeup, ultimately enhancing therapeutic outcomes while mitigating adverse effects.
Investigating JAK/STAT SNPs builds upon the background information provided on the JAK/STAT signaling pathway, aiming to understand its critical role in various biological processes like organ development, immune response, and disease pathogenesis. Researchers seek to elucidate how genetic variations within the JAK/STAT genes may influence pathway function and contribute to disease susceptibility or treatment response. SNPs within JAK/STAT genes have the potential to alter the function of key signaling molecules, such as JAKs and STATs, thereby affecting downstream cellular responses. Understanding the association between specific SNPs and diseases, such as autoimmune disorders or cancer, can provide valuable insights into disease mechanisms and inform personalized medicine approaches. Therefore, the study goal of investigating JAK/STAT SNPs is to uncover genetic determinants that contribute to disease risk or treatment outcomes, ultimately aiming to improve patient care through tailored interventions based on individual genetic profiles.
We welcome the submission of Original Research, Review/Mini Review, and Clinical Trial articles covering, but not limited to, the following research areas:
• Genetic Variation and Pathway Function: Studies that aim to explore how specific SNPs within JAK/STAT genes influence the function of the JAK/STAT signaling pathway. This includes understanding how genetic variations may alter the activity of key signaling molecules and impact downstream cellular responses.
• Disease Association: Studies that seek to elucidate the association between JAK/STAT SNPs and various diseases, particularly autoimmune disorders and cancer. By identifying specific genetic variants linked to disease susceptibility, studies aim to shed light on the underlying mechanisms and potential therapeutic targets.
• Treatment Response: Studies that investigate how genetic variations within the JAK/STAT pathway may influence treatment response, particularly to therapies targeting this pathway. Understanding how SNPs impact treatment efficacy and side effects can inform personalized medicine approaches, guiding treatment decisions based on individual genetic profiles.
• Clinical Implications: Studies that provide clinical insights into the therapeutic potential of targeting the JAK/STAT signaling pathway, particularly through the use of JAK/STAT/TYK2 inhibitors. This includes discussing signal transduction mechanisms, molecular pathways involved in immune function and disease, and evidence from clinical trials supporting the efficacy of targeted therapies.
Original Research articles that contain novel and prominent information of general interest to researchers in these fields are highly appreciated.
Keywords:
JAK/STAT pathway; variants/SNP; immune disorder; autoimmune diseases; cancer, leukemia; metabolic disorder; cytokines; JAK inhibitors
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The JAK/STAT signaling pathway is pivotal in organ development, governing key cellular processes like proliferation, differentiation, and survival. It responds to a spectrum of cytokines and growth factors, crucial for immune response, tissue differentiation, and organ function, including mammary glands and liver. Dysregulation of this pathway, characterized by aberrant JAK/STAT transduction, can have far-reaching consequences. It triggers proinflammatory cytokine signaling, disrupting immune homeostasis and fostering the development of autoimmune diseases. Additionally, dysregulation of the JAK/STAT pathway is implicated in various metabolic disturbances such as fatty liver, diabetes, and contributes to the development of cancer. Therefore, maintaining the proper functioning of the JAK/STAT pathway is essential for overall organ health and systemic homeostasis.
Variations within JAK/STAT genes can alter the function of critical components like JAKs and STATs, impacting immune responses and predisposing individuals to autoimmune conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, as well as certain cancers. Moreover, these genetic variations influence responses to drugs targeting the JAK/STAT pathway, affecting treatment efficacy and side effects. Consequently, deciphering these genetic nuances holds promise for personalized medicine, enabling tailored treatments aligned with an individual's genetic makeup, ultimately enhancing therapeutic outcomes while mitigating adverse effects.
Investigating JAK/STAT SNPs builds upon the background information provided on the JAK/STAT signaling pathway, aiming to understand its critical role in various biological processes like organ development, immune response, and disease pathogenesis. Researchers seek to elucidate how genetic variations within the JAK/STAT genes may influence pathway function and contribute to disease susceptibility or treatment response. SNPs within JAK/STAT genes have the potential to alter the function of key signaling molecules, such as JAKs and STATs, thereby affecting downstream cellular responses. Understanding the association between specific SNPs and diseases, such as autoimmune disorders or cancer, can provide valuable insights into disease mechanisms and inform personalized medicine approaches. Therefore, the study goal of investigating JAK/STAT SNPs is to uncover genetic determinants that contribute to disease risk or treatment outcomes, ultimately aiming to improve patient care through tailored interventions based on individual genetic profiles.
We welcome the submission of Original Research, Review/Mini Review, and Clinical Trial articles covering, but not limited to, the following research areas:
• Genetic Variation and Pathway Function: Studies that aim to explore how specific SNPs within JAK/STAT genes influence the function of the JAK/STAT signaling pathway. This includes understanding how genetic variations may alter the activity of key signaling molecules and impact downstream cellular responses.
• Disease Association: Studies that seek to elucidate the association between JAK/STAT SNPs and various diseases, particularly autoimmune disorders and cancer. By identifying specific genetic variants linked to disease susceptibility, studies aim to shed light on the underlying mechanisms and potential therapeutic targets.
• Treatment Response: Studies that investigate how genetic variations within the JAK/STAT pathway may influence treatment response, particularly to therapies targeting this pathway. Understanding how SNPs impact treatment efficacy and side effects can inform personalized medicine approaches, guiding treatment decisions based on individual genetic profiles.
• Clinical Implications: Studies that provide clinical insights into the therapeutic potential of targeting the JAK/STAT signaling pathway, particularly through the use of JAK/STAT/TYK2 inhibitors. This includes discussing signal transduction mechanisms, molecular pathways involved in immune function and disease, and evidence from clinical trials supporting the efficacy of targeted therapies.
Original Research articles that contain novel and prominent information of general interest to researchers in these fields are highly appreciated.
Keywords:
JAK/STAT pathway; variants/SNP; immune disorder; autoimmune diseases; cancer, leukemia; metabolic disorder; cytokines; JAK inhibitors
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.