Thymus Research and Development: A New Look to the Past, Current Knowledge, and Future Perspectives

  • 1,291

    Total Downloads

  • 4,479

    Total Views and Downloads

About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 31 December 2024

  2. This Research Topic is still accepting articles.

Background

Research on the thymus is one of the most intriguing pages in the history of the development and establishment of immunology as a science. Since the discovery of the thymus in the early 1960s by the Australian scientist Jacques Miller and the assessment of its role as a central organ of immunity, research in this area has been controversial - from the recognition of the critical role of the thymus in the formation of the T-cell repertoire and control of the adaptive immune system function up to the denying thymus role as a vital organ. Contrary to the objections of immunologists, the formation of this opinion, in particular, was facilitated by the radical position of surgeons on the need for complete or partial thymectomy during cardiac surgery in children. For several reasons, the long-term consequences of such operations remain poorly understood to date. Technogenic influence on the human immune system and the intensification of life in modern post-industrial society create additional risks of deep chronic immunosuppression, which primarily affects the function of the thymus and manifests itself in accelerated immunosenescence as a whole and the development of immunoassociated diseases. Today, this dynamic field of research is experiencing a new peak of interest, intriguing discoveries and encouraging prospects, and new research and biotechnological opportunities require a critical assessment of accumulated scientific data and a rethinking of established views and dogmas.

The purpose of this Research Topic is to present different points of view on the role of the thymus in the structure of the immune system, its formation and functioning from the perspective of modern knowledge based on single-cell sequencing technologies, molecular cloning, gene editing, generation of pluripotent stem cells, growing of artificial organs and organoids, including the use of microfluidic chip technologies, modern image technologies, artificial intelligence and machine learning in modeling biotechnological processes, obtaining and evaluating new scientific data and their correct application in medical practice. The topic's articles should serve not only as a critical examination of existing evidence or present original data but also as a motivator and guide for future research, innovation and research cooperation.

Scope and information for Authors: The scope of the Research Topic addresses contributions to the next specific themes:

• Thymus structure and function

• Thymus research and developments

• Thymus and adaptive immunity

• Thymus and innate immunity

• Thymus-associated diseases

• Thymus regeneration

• Humanized thymus models

• Thymic organoids and cell cultures

• Molecular markers of thymic function and dysfunction

• Intrathymic signaling and crosstalk

• Intrathymic cytokine, chemokine and hormonal network

• Thymic cell populations

Research papers, reviews, perspectives, mini reviews, short communications, and opinions are welcome. Please note that pure clinical studies are unsuitable for this special issue.

Dr. Valentin Shichkin is employed by the private company OmniFarma, LLC.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Thymus, Thymus development and function, Thymus regeneration, Immune system, Immunosenescence, Thymus-associated diseases, Intrathymic stem cells, Stem cell technologies.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and they fall under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

      In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 4,479Topic views
  • 2,622Article views
  • 1,291Article downloads
View impact