Dopaminoceptive Forebrain Regions: A Search for Structural and Functional Organization Underlying Normal and Impaired Social Adaptation

The field of neuroscience has long been captivated by the intricate role of dopaminergic neurotransmission within the brain, particularly focusing on the ascending dopaminergic pathways that originate from the brainstem and extensively innervate the forebrain's cortical and subcortical regions. Dopamine, a key monoamine, is involved in a myriad of regulatory systems, influencing locomotor organization, reward and motivation, and cognitive flexibility through various pathways such as the nigrostriatal, mesolimbic, and mesocortical systems. Despite the extensive research on dopamine receptors and signaling pathways, the neuroanatomical organization of dopaminoceptive regions remains a critical area of investigation. Current studies have highlighted the significance of these regions in human diseases like Parkinsonism, emotional disturbances, and social maladaptation conditions, including Autism Spectrum Disorder (ASD). However, there is a pressing need to further explore the structural and functional organization of these brain regions to better understand their role in both normal and impaired social adaptation.

This research topic aims to delve into the structural and functional organization of dopaminoceptive forebrain regions, with a particular focus on their role in social adaptation. The primary objective is to unravel the complexities of dopaminergic pathways and their interactions with various forebrain targets, thereby enhancing our understanding of their contribution to both normal and impaired social behaviors. Key questions include how the distribution and availability of dopamine receptors influence social adaptation and what neuroanatomical features are critical in these processes. The research will also test hypotheses related to the 'dopamine theory' of Autism and other social maladaptation conditions.

To gather further insights into the structural and functional organization of dopaminoceptive forebrain regions, we welcome articles addressing, but not limited to, the following themes:
- Neuroanatomical mapping of dopaminergic pathways in the forebrain
- Comparative studies on dopaminergic systems across species
- Developmental aspects of dopaminergic innervation in social behavior
- Neurochemical analyses of dopamine receptor distribution and function
- Functional studies linking dopaminergic activity to social adaptation
- Translational research connecting animal models to human clinical observations
- Reviews and opinion pieces on the current state and future directions of dopaminergic research in social adaptation.