Current Insights in Melanoma Immunology, Immune Escape and Immunotherapy Advances

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 22 February 2025

  2. This Research Topic is still accepting articles.

Background

Melanoma is a highly immunogenic tumor, characterized by the expression of multiple tumor-associated antigens that can be recognized and targeted by the host immune system. Despite the potential for spontaneous immune responses against these antigens, melanoma cells often employ various mechanisms to evade immune detection, such as downregulating targetable molecules and overexpressing immunosuppressive cytokines. Over the past decade, the introduction of immune checkpoint inhibitors (ICIs) like ipilimumab has significantly improved outcomes for patients with advanced melanoma. However, a substantial number of patients still experience primary or acquired resistance to these therapies, highlighting the need for a deeper understanding of the immune dynamics at play. Recent studies have focused on the tumor immune microenvironment and the interplay between melanoma cells and immunotherapeutic agents, yet gaps remain in fully elucidating the mechanisms of immune escape and resistance. 
 
This research topic aims to compile a comprehensive collection of articles that explore the complex mechanisms underlying melanoma immunology and the rationale for immunotherapy. The primary objective is to elucidate the diverse effects of the expanding array of immunotherapeutic agents and to identify critical immunologic pathways involved in the anti-melanoma immune response. Additionally, the research will focus on molecular and cellular biomarkers that can guide personalized immunotherapeutic decisions and aid in managing immune-related adverse events. By addressing these areas, the research seeks to advance the understanding of melanoma immunotherapy and improve patient outcomes. 
 
To gather further insights in the intricate field of melanoma immunology and immunotherapy, we welcome articles addressing, but not limited to, the following themes: 
- Tumor immune microenvironment dynamics and factors contributing to immune evasion. 
- Clinical effects of immunotherapy on different immune cell subsets in melanoma patients. 
- Mechanisms of melanoma resistance to immunotherapy, both intratumoral and systemic. 
- Identification and validation of cellular or molecular biomarkers for predicting immunotherapy response. 
- Novel pathophysiological, genetic, and epigenetic models for evaluating melanoma evolution and treatment. 
- Strategies for enhancing immune response in early and advanced melanoma. 
- Preclinical and clinical evidence on combining immunotherapeutic approaches. 
- Exploration of new checkpoint molecules and other targetable immunologic candidates. 
- The synergistic or non-synergistic roles of targeting various molecules and pathways. 
- Clinical data on diagnosing and managing immune-related adverse events. 

Please note that Dr. Pedro Berraondo reports research funding from Moderna, Affimed, Hookipa, and Bavarian Nordic and speaker honoraria from BMS, MSD, Novartis, and AstraZeneca.

Please also note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Melanoma microenvironment, immunologic biomarkers, immunotherapy, immunotherapy resistance, immune checkpoint inhibitors, vaccines, INT

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Impact

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