Viral infections continue to pose a significant threat to global health, causing substantial morbidity and mortality. With the emergence of novel viruses and the increasing burden of resistant strains, the need for potent and broad-spectrum antiviral agents is urgent. However, traditional drug discovery approaches have fallen short, highlighting the critical need for innovative strategies.
This Research Topic aims to explore and advance cutting-edge methods for uncovering promising antiviral agents. We welcome researchers from diverse disciplines, including virology, pharmacology, computational biology, nanotechnology, and natural product chemistry, to collaborate and contribute their expertise. By fostering interdisciplinary research and embracing innovative approaches, we can accelerate the development of effective and accessible antiviral agents, ultimately significantly impacting global health.
This Research Topic will encompass a broad range of innovative approaches to antiviral drug discovery, focusing on, but not limited to the following themes:
- Targeting novel viral components: Shifting focus beyond traditional targets like viral enzymes to novel components like host-virus interaction interfaces, regulatory pathways, and non-coding RNAs could yield unique therapeutic opportunities. Exploring untapped viral families with high public health impact.
- Leveraging artificial intelligence, machine learning, and structural modeling can accelerate the identification of candidate drugs, predict efficacy and resistance profiles, and guide rational drug design.
- Repurposing existing drugs: Exploring the potential of existing drugs for repurposing against viral targets has the advantage of reduced timelines and lower costs compared to de novo drug development.
- Developing alternative delivery systems: Nanocarriers, prodrugs, and gene therapy vectors can improve drug targeting, enhance bioavailability, and overcome barriers to viral reservoirs.
- Exploring unconventional natural sources: Bioprospecting marine environments, extremophiles, and understudied microbial communities can provide diverse lead compounds with unique antiviral properties. Exploring alternative sources like host immunity pathways and viral modification enzymes for potential therapeutic agents.
- Collaborative framework: Encouraging interdisciplinary research collaborations between virologists, pharmacologists, computational biologists, nanotechnologists, and natural product chemists. Establishing platforms for data sharing, knowledge exchange, and joint research projects.
Keywords:
novel targets, antiviral therapy, antiinfective agents, drugs against pandemice potential agents, drug discovery, drugs against pandemics potential agents
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Viral infections continue to pose a significant threat to global health, causing substantial morbidity and mortality. With the emergence of novel viruses and the increasing burden of resistant strains, the need for potent and broad-spectrum antiviral agents is urgent. However, traditional drug discovery approaches have fallen short, highlighting the critical need for innovative strategies.
This Research Topic aims to explore and advance cutting-edge methods for uncovering promising antiviral agents. We welcome researchers from diverse disciplines, including virology, pharmacology, computational biology, nanotechnology, and natural product chemistry, to collaborate and contribute their expertise. By fostering interdisciplinary research and embracing innovative approaches, we can accelerate the development of effective and accessible antiviral agents, ultimately significantly impacting global health.
This Research Topic will encompass a broad range of innovative approaches to antiviral drug discovery, focusing on, but not limited to the following themes:
- Targeting novel viral components: Shifting focus beyond traditional targets like viral enzymes to novel components like host-virus interaction interfaces, regulatory pathways, and non-coding RNAs could yield unique therapeutic opportunities. Exploring untapped viral families with high public health impact.
- Leveraging artificial intelligence, machine learning, and structural modeling can accelerate the identification of candidate drugs, predict efficacy and resistance profiles, and guide rational drug design.
- Repurposing existing drugs: Exploring the potential of existing drugs for repurposing against viral targets has the advantage of reduced timelines and lower costs compared to de novo drug development.
- Developing alternative delivery systems: Nanocarriers, prodrugs, and gene therapy vectors can improve drug targeting, enhance bioavailability, and overcome barriers to viral reservoirs.
- Exploring unconventional natural sources: Bioprospecting marine environments, extremophiles, and understudied microbial communities can provide diverse lead compounds with unique antiviral properties. Exploring alternative sources like host immunity pathways and viral modification enzymes for potential therapeutic agents.
- Collaborative framework: Encouraging interdisciplinary research collaborations between virologists, pharmacologists, computational biologists, nanotechnologists, and natural product chemists. Establishing platforms for data sharing, knowledge exchange, and joint research projects.
Keywords:
novel targets, antiviral therapy, antiinfective agents, drugs against pandemice potential agents, drug discovery, drugs against pandemics potential agents
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.