About this Research Topic
According to statistics from the National Cancer Center, there will be approximately 514,000 new cases of gastric cancer in 2023, making it the second most common malignant tumor. In 2019, the World Health Organization classified gastric cancer into papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, and poorly cohesive carcinoma based on histological types. Although these classification methods are straightforward, they overly rely on subjective judgment, overlooking the high heterogeneity between differing pathological subtypes of gastric cancer.
Poorly Cohesive Cells-Gastric Cancer (PCC-GC) consists of scattered cancer cells, appearing as isolated cells or small clusters. Its degree of malignancy is relatively high, and it belongs to low-differentiated cancer, often manifesting as gastric signet ring cell carcinoma type. The adhesion between its cancer cells is relatively poor, without a distinct glandular structure, making it susceptible to infiltration, metastasis, and diffusion. Due to its low sensitivity to drugs, the prognosis of patients is worse than other types of gastric cancer.
The pathogenesis process and molecular mechanisms of PCC-GC are not yet clearly defined. Understanding its natural evolution and molecular phenotype can reveal its correlation with clinical characteristics, treatment response, tumor drug resistance, and prognosis. Exploring its driver genes and discovering drugs targeting these genes may provide a theoretical basis for conquering PCC-GC.
This Research Topic seeks to provide current insights into the pathogenesis, molecular mechanisms, and potential therapeutic strategies involved in PCC-GC. Original Research articles and Reviews and Case Report are welcome, including but not limited to the following contents:
1. Research related to the immune microenvironment, transcriptional heterogeneity, and serum metabolomics of poorly cohesive cells-gastric cancer.
2. Research on the mechanism of the relationship between intercellular adhesion molecules and the invasion and metastasis of poorly cohesive cells-gastric cancer.
3. Research on the mechanism of matrix stiffness and matrix cell activation in the multidrug resistance of poorly cohesive cells-gastric cancer.
4. Research on the imaging characteristics of poorly cohesive cells-gastric cancer and its correlation with pathological grading.
Poorly Cohesive Cells-Gastric Cancer (PCC-GC) consists of scattered cancer cells, appearing as isolated cells or small clusters. Its degree of malignancy is relatively high, and it belongs to low-differentiated cancer, often manifesting as gastric signet ring cell carcinoma type. The adhesion between its cancer cells is relatively poor, without a distinct glandular structure, making it susceptible to infiltration, metastasis, and diffusion. Due to its low sensitivity to drugs, the prognosis of patients is worse than other types of gastric cancer.
The pathogenesis process and molecular mechanisms of PCC-GC are not yet clearly defined. Understanding its natural evolution and molecular phenotype can reveal its correlation with clinical characteristics, treatment response, tumor drug resistance, and prognosis. Exploring its driver genes and discovering drugs targeting these genes may provide a theoretical basis for conquering PCC-GC.
This Research Topic seeks to provide current insights into the pathogenesis, molecular mechanisms, and potential therapeutic strategies involved in PCC-GC. Original Research articles and Reviews and Case Report are welcome, including but not limited to the following contents:
1. Research related to the immune microenvironment, transcriptional heterogeneity, and serum metabolomics of poorly cohesive cells-gastric cancer.
2. Research on the mechanism of the relationship between intercellular adhesion molecules and the invasion and metastasis of poorly cohesive cells-gastric cancer.
3. Research on the mechanism of matrix stiffness and matrix cell activation in the multidrug resistance of poorly cohesive cells-gastric cancer.
4. Research on the imaging characteristics of poorly cohesive cells-gastric cancer and its correlation with pathological grading.
Keywords: Poorly Cohesive Cells, Gastric Cancer, Pathogenesis, Molecular Mechanisms, Therapeutic Strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
