About this Research Topic
Kinetoplastids are a group of unicellular organisms that include some pathogenic parasites that could affect humans and other animals. Some of the most important diseases caused by kinetoplastids include sleeping sickness, Chagas disease, and leishmaniasis. These pathologies are inserted in the neglected tropical diseases (NTDs), a group of diseases characterized by their incidence in tropical and subtropical areas and by the lack of concern for their control by the international community and pharmaceutical companies.
These pathologies present challenges for control due to some factors. The complex life cycles of the parasites, the toxicity of the actual treatments, the lack of adequate diagnostics, drug resistance, and the difficulty in controlling the vectors make it harder to control these pathologies. To address these diseases effectively requires a comprehensive approach that includes improving access to health services, developing more effective diagnostic and treatment tools, as well as implementing vector control and prevention measures.
The current research topic focuses on the search for new therapies for diseases caused by kinetoplastids (Leishmaniasis, Chagas Disease, and Sleeping Sickness). This will include in vitro and in vivo assays against the parasites, as well as toxicity studies of the new compounds tested. In addition, it will be appropriate to include studies on the type of cell death induced by the new compounds in the parasites. Other studies, such as metabolomics or proteomics, or the assays related to the ADME (absorption, distribution, metabolism, and elimination).
These pathologies present challenges for control due to some factors. The complex life cycles of the parasites, the toxicity of the actual treatments, the lack of adequate diagnostics, drug resistance, and the difficulty in controlling the vectors make it harder to control these pathologies. To address these diseases effectively requires a comprehensive approach that includes improving access to health services, developing more effective diagnostic and treatment tools, as well as implementing vector control and prevention measures.
The current research topic focuses on the search for new therapies for diseases caused by kinetoplastids (Leishmaniasis, Chagas Disease, and Sleeping Sickness). This will include in vitro and in vivo assays against the parasites, as well as toxicity studies of the new compounds tested. In addition, it will be appropriate to include studies on the type of cell death induced by the new compounds in the parasites. Other studies, such as metabolomics or proteomics, or the assays related to the ADME (absorption, distribution, metabolism, and elimination).
Keywords: Trypanosoma, Leishmania, Trypanosomiasis, Leishmaniasis
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