Epigenetic Regulation in Fibrosis

Epigenetic regulation plays a pivotal role in the pathogenesis of fibrosis, a pathological condition characterized by excessive deposition of extracellular matrix components, leading to tissue scarring and dysfunction of various organs including the heart, liver, lung, kidney, and skin. Despite significant advances in understanding the molecular and cellular mechanisms underlying fibrosis, the precise role of epigenetic modifications in this process remains incompletely understood. Recent studies have highlighted the importance of DNA methylation, histone modifications, and non-coding RNA regulation in the activation of fibrogenic pathways. However, there are still substantial gaps in our knowledge regarding how these epigenetic changes are orchestrated and how they contribute to disease progression. Addressing these gaps is crucial for the development of novel therapeutic strategies and precision medicine approaches aimed at mitigating fibrosis.

This research topic aims to explore the dynamic epigenetic changes underlying fibrosis, understand the molecular mechanisms driving disease progression, and identify potential therapeutic interventions to mitigate fibrosis. The primary goal is to address the gap in our understanding of epigenetic mechanisms involved in fibrosis. We aim to bring together researchers to explore how epigenetic changes influence the initiation and progression of fibrotic diseases. Furthermore, this research topic will also highlight potential therapeutic interventions and precision medicine approaches that can be utilized to mitigate fibrosis by targeting various epigenetic pathways. We hope this research topic can finally facilitate the clinical treatment of patients with fibrotic diseases.

To gather further insights into the epigenetic regulation in fibrosis, we welcome articles addressing, but not limited to, the following themes:

- Mechanisms and functions of DNA, histone, or other chromatin modifications in fibrosis
- Non-coding RNA regulation and function in fibrosis
- Mechanisms and functions of RNA modification and function in fibrosis
- Epigenetic regulation related to fibrosis mitigation and treatment

We welcome original research articles, reviews, case reports, and perspectives that provide new insights into the epigenetic landscape of fibrosis. Authors from diverse affiliations and geographic regions are encouraged to contribute, ensuring a comprehensive and global perspective on this critical area of research.

Keywords: fibrosis, DNA methylation, Epigenetics, Histone Modification, RNA modification, Non-coding RNA, Fibrogenesis pathways, Extracellular Matrix, Precision medicine development

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.