Perspectives And Recent Advances In Rare Liver Diseases In Children

Rare liver diseases are increasingly numerous due to continuous new discoveries in the field of genetics and are attracting more and more interest in recent years. For many of them, which have been known for decades, many diagnostic and therapeutic aspects still remain to be clarified. At the same time, in recent years, new drugs for the treatment of these conditions have been developed and are being studied. It is likely that new therapeutic strategies may also modify the natural history of some of these disorders. In some cases, in fact, it cannot be excluded that new genetic and pharmacological therapies could reduce the need for liver transplantation.

The proposed Research Topic aims to provide an update on the various aspects of rare liver diseases in children and to provide an overview of the perspectives and recent progress made in the management of children suffering from a rare liver disease.

In the proposed Research Topic we aim to focus on recent advances in the management of rare liver diseases in children with particular emphasis on diagnostic pitfalls, recent innovations in the field of diagnosis and therapeutic monitoring, innovative therapeutic approaches, emerging drugs and multidisciplinary collaboration.

We welcome Original Research articles, Case Reports, Comments, Reviews/ Mini-Reviews, Systematic Reviews, Short Reports.

Keywords: IBAT inhibitors, Alagille syndrome, Wilson's Disease, PFIC, Biliary Atresia, Crigler Najjar Syndrome, gene therapy, metabolic liver disease.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.