Muscle Stem Cell for Skeletal Muscle Regeneration

Skeletal muscle, the most abundant tissue in the body, is present across a wide range of species, from coelenterates to vertebrates. Its remarkable regenerative capacity is attributed to muscle stem cells, also known as satellite cells, which reside in adult skeletal muscle. These cells are crucial for muscle growth and repair, as they differentiate into myofibers upon activation. Satellite cells typically exist in a quiescent state but are activated by stimuli such as exercise or trauma, leading to their division and transformation into muscle progenitor cells. These progenitor cells proliferate, eventually fusing to form or repair myofibers, while some revert to a stem cell state, ensuring ongoing muscle regeneration. Despite significant advancements in understanding satellite cell biology, gaps remain in fully elucidating their mechanisms and potential therapeutic applications. Current research is focused on harnessing their regenerative capabilities to address muscle damage due to disease, injury, or aging, yet further investigation is needed to optimize these approaches.

This Research Topic aims to explore the biology of satellite cells and their potential in regenerative medicine for skeletal muscle repair. The primary objectives include understanding the mechanisms of satellite cell activation, proliferation, and differentiation, as well as their self-renewal capabilities. Additionally, we seek to investigate the therapeutic applications of satellite cells in treating muscle diseases and age-related muscle atrophy, providing insights into novel regenerative strategies.

To gather further insights in the field of muscle stem cell research for skeletal muscle regeneration, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms of satellite cell activation and differentiation
- Role of satellite cells in muscle growth and repair
- Satellite cell self-renewal and maintenance of muscle performance
- Therapeutic applications of satellite cells in muscle diseases
- Regenerative strategies for age-related muscle atrophy
- Advances in stem cell-based regenerative medicine for skeletal muscle repair

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: skeletal muscle, satellite cells, muscle atrophy, muscle repair

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.