About this Research Topic
Single-cell sequencing technology allows us to analyze the genetic and phenotypic heterogeneity of tumor cells at the single-cell level, revealing mechanisms of tumor progression and treatment resistance. Spatial transcriptomics, on the other hand, provides a way to map gene expression patterns in the context of tissue structure, helping us to more fully understand the tumor microenvironment and its impact on tumor heterogeneity and progression. These bioinformatics approaches help researchers to parse large-scale histological data to reveal deeper mechanisms of tumor biology and potential therapeutic targets. Meanwhile, the special issue will also focus on how to screen and validate new biomarkers through these high-throughput technologies, which are expected to be used as diagnostic tools or prognostic indicators to help clinicians make more precise choices in individualized treatment decisions.
In addition, this Research Topic encourages the submission of papers related to the application of single-cell sequencing and spatial transcriptomics in tumor drug target discovery and drug delivery system development. These advanced technologies not only help to identify new drug targets, but also reveal the mechanism of drug action and the molecular basis of drug resistance. For experts in the field of pharmaceutical biology, these discoveries will provide important insights that will help develop personalized therapeutics and more effective drug delivery systems for specific tumor subtypes. Through such studies, we can better understand how drugs function in the tumor microenvironment and provide new ideas for precision medicine and drug development.
The aim of this Research Topic is to bring together the latest research results and explore how these cutting-edge technologies can be used to gain a deeper understanding of the molecular mechanisms of digestive tumors, identify new biomarkers, and guide more effective diagnostic and therapeutic strategies. We particularly focus on the following areas:
--Drug Discovery and Delivery: Exploring the role of single-cell sequencing and spatial transcriptomics in identifying novel drug targets and enhancing drug delivery mechanisms for personalized treatment strategies in digestive system tumors.
--Understanding Tumor Heterogeneity: To explore the diverse cellular populations within digestive system tumors using single-cell sequencing, revealing insights into tumor progression and resistance mechanisms.
--Analyzing the Tumor Microenvironment: To examine the complex interactions within the tumor microenvironment, utilizing spatial transcriptomics for a detailed understanding of the spatial and architectural context of these interactions.
--Identifying Novel Biomarkers: To discover and validate new biomarkers for early detection, prognosis, and targeted therapies using advanced omics technologies.
--Advancing Therapeutic Strategies: To investigate how these high-resolution molecular profiles can inform personalized treatment approaches, including understanding drug resistance and potential therapeutic targets.
--Integrating Multi-Omics Data: To combine single-cell and spatial transcriptomics with other omics approaches for a comprehensive molecular understanding of digestive system tumors.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Single-cell sequencing, Multi-Omics Data, Drug Discovery and Delivery, Tumor Heterogeneity, Tumor Microenvironment, Novel Biomarkers, Therapeutic Strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.