About this Research Topic
Extracellular vesicle (EV) research has rapidly advanced over the past decades, from fundamental science to translational applications. However, critical questions remain regarding EV biology and mechanisms of action, particularly in EV-cell interactions. EVs are hypothesized to mediate intercellular communication through cargo transfer, yet EV-cargo delivery between cells remains difficult to elucidate and quantify. Addressing these fundamental knowledge gaps, as well as technological barriers in characterizing and engineering EVs, will accelerate the potential clinical translation of EVs in therapeutics and diagnostics.
Recognizing these field-specific challenges, this Research Topic aims to:
• Better understand the interactions between EVs and complex biological systems and provide a platform to elaborate possible cellular or molecular mechanisms involved in EV diagnostics and therapeutics.
• Share rationally designed strategies to surmount existing physiological challenges and clinical translational hurdles, which are expected to provide new research directions for the development of novel EV-based nano-/biomaterials in cancer interventions and tissue repair.
• Identify the pros and cons of innovative EV-based systems for precision nanomedicine and regenerative medicine, and ultimately accelerate the translation of these EV-based systems from fundamental research to clinical medicine.
• Emphasize novel approaches to facilitate understanding of EV biology, address outstanding questions, and leverage this knowledge to advance EV diagnostics and therapeutics.
This Research Topic focuses on promising innovative strategies using versatile EV-based materials for therapeutics and diagnostics. Both original research papers and review articles with significant findings or viewpoints are welcome. Preferred themes include but are not limited to:
• Innovative strategies for designing versatile EV biomaterials
• EV-based drug and nucleic acid delivery
• EV-based diagnostics and therapeutics
• Technical improvements in EV isolation and characterization for clinical applications
• New understanding of EV biogenesis, molecular composition, functions, and physio-pathological roles
Recognizing these field-specific challenges, this Research Topic aims to:
• Better understand the interactions between EVs and complex biological systems and provide a platform to elaborate possible cellular or molecular mechanisms involved in EV diagnostics and therapeutics.
• Share rationally designed strategies to surmount existing physiological challenges and clinical translational hurdles, which are expected to provide new research directions for the development of novel EV-based nano-/biomaterials in cancer interventions and tissue repair.
• Identify the pros and cons of innovative EV-based systems for precision nanomedicine and regenerative medicine, and ultimately accelerate the translation of these EV-based systems from fundamental research to clinical medicine.
• Emphasize novel approaches to facilitate understanding of EV biology, address outstanding questions, and leverage this knowledge to advance EV diagnostics and therapeutics.
This Research Topic focuses on promising innovative strategies using versatile EV-based materials for therapeutics and diagnostics. Both original research papers and review articles with significant findings or viewpoints are welcome. Preferred themes include but are not limited to:
• Innovative strategies for designing versatile EV biomaterials
• EV-based drug and nucleic acid delivery
• EV-based diagnostics and therapeutics
• Technical improvements in EV isolation and characterization for clinical applications
• New understanding of EV biogenesis, molecular composition, functions, and physio-pathological roles
Keywords: extracellular vesicles, exosomes, diagnostics, therapeutics, nanomedicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
