About this Research Topic
Mendelian randomization (MR) represents a valuable methodology to address the causal relationships between an exposure and an outcome. In MR studies, instrumental variables associated with the exposure are carefully selected, with alleles being randomly assigned according to Mendel's second law of inheritance. Analogous to a natural randomized clinical trial (RCT), the MR methodology enables researchers to circumvent potential confounding variables and offers unique advantages in elucidating the causal relationship between risk factors and outcomes, particularly in understanding the causal relationship between risk factors and cardiovascular remodeling.
Previous MR studies have provided robust evidence of the strong associations between certain risk factors and cardiovascular diseases. For instance, conclusive causal relationships have been established between sleep apnea and hypertension. However, there remain gaps in our understanding of causal relationships between some risk factors and cardiovascular remodeling. For example, the causality between sleep apnea and pulmonary artery hypertension has not yet been established. The lack of precise causality hampers our abilities to comprehensively investigate the etiology, pathophysiology, measurement techniques, and potential therapies for cardiovascular remodeling. Thus, it is imperative to analyze the causality between risk factors and cardiovascular remodeling using MR or alternative methodologies. In addition, the presence of mediating factors in the pathogenesis of risk factor-induced cardiovascular remodeling requires further investigation.
In this Research Topic, we welcome researchers to submit original research articles and review articles that will contribute to the field of the causality between risk factors and cardiovascular remodeling, with a special emphasis on MR studies. We welcome clinical studies and pooled analyses focusing on the etiology, pathophysiology, measurement approaches, and therapeutic interventions for cardiovascular remodeling, including hypertension, coronary artery disease, chronic heart failure, aortic aneurysm, and so on.
This Research Topic is interested in, but not limited to, the following research fields:
• MR studies investigating the correlations between oxidative stress, inflammation, hypoxia, metabolic abnormalities, diets, and other risk factors, across an array of cardiovascular diseases such as hypertension, coronary artery disease, chronic heart failure, atrial fibrillation, pulmonary artery hypertension, aortic aneurysm, and more.
• Research employing alternate analytical methods or clinical studies that examine the causal relationships between risk factors and cardiovascular remodelling.
• examine the etiology, pathophysiology, measurement methodologies, and therapeutic interventions of cardiovascular remodelling through multidisciplinary perspectives.
Previous MR studies have provided robust evidence of the strong associations between certain risk factors and cardiovascular diseases. For instance, conclusive causal relationships have been established between sleep apnea and hypertension. However, there remain gaps in our understanding of causal relationships between some risk factors and cardiovascular remodeling. For example, the causality between sleep apnea and pulmonary artery hypertension has not yet been established. The lack of precise causality hampers our abilities to comprehensively investigate the etiology, pathophysiology, measurement techniques, and potential therapies for cardiovascular remodeling. Thus, it is imperative to analyze the causality between risk factors and cardiovascular remodeling using MR or alternative methodologies. In addition, the presence of mediating factors in the pathogenesis of risk factor-induced cardiovascular remodeling requires further investigation.
In this Research Topic, we welcome researchers to submit original research articles and review articles that will contribute to the field of the causality between risk factors and cardiovascular remodeling, with a special emphasis on MR studies. We welcome clinical studies and pooled analyses focusing on the etiology, pathophysiology, measurement approaches, and therapeutic interventions for cardiovascular remodeling, including hypertension, coronary artery disease, chronic heart failure, aortic aneurysm, and so on.
This Research Topic is interested in, but not limited to, the following research fields:
• MR studies investigating the correlations between oxidative stress, inflammation, hypoxia, metabolic abnormalities, diets, and other risk factors, across an array of cardiovascular diseases such as hypertension, coronary artery disease, chronic heart failure, atrial fibrillation, pulmonary artery hypertension, aortic aneurysm, and more.
• Research employing alternate analytical methods or clinical studies that examine the causal relationships between risk factors and cardiovascular remodelling.
• examine the etiology, pathophysiology, measurement methodologies, and therapeutic interventions of cardiovascular remodelling through multidisciplinary perspectives.
Keywords: Mendelian randomization, inverse-variance weighted, hypertension, coronary artery disease, heart failure, aortic aneurysm
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