About this Research Topic
Nowadays Oral Health and Oral Care are successfully driven by daily preventive, hygiene routines mechanically mitigating the biofilm burden facilitated by antimicrobial ingredients.
Nevertheless, periodontal disease affects more than 700 million people, making it one of the most prevalent chronic inflammatory diseases worldwide while dental cariogenicity still account as one of the most relevant health disorders in the industrialized world with more than 2 billion cases worldwide. Both diseases cause a tremendous social and economic burden for governmental healthcare systems.
In the last 20 years interruptive scientific advancements in life science and big data paved the road for a richness of detail on various functional levels of biological life. Next generation sequencing allows the insight in polymicrobial communities, inter-microbial and host-microbial interaction beyond community profiling on a yet unseen resolution. In fact, integration of metagenomic and metatranscriptomic data with dysbiotic disease strongly suggests a functional transcriptomic redundancy despite dispersal in the polymicrobial community composition.
In fact, the multifactorial character of oral diseases, strongly insinuated by exogenous parameters and the relevance of the multispecies equilibrium within a phylogenetic ecological framework clearly culminates and integrates the ecological plaque hypothesis with the polymicrobial synergy and dysbiosis model.
Still, even keystone pathogens have their distinct role by driving disease progression. Inflammophilic organisms orchestrate the host immune response, modulating the otherwise pathogen-detrimental inflammatory response to a more dysbiotic-stabilizing, beneficial answer. Certainly, the host immune response from innate defenses to immune tolerance of commensal bacteria contribute as key player to the equilibrium of the oralome and eubiosis.
With this said, we are interested in new insights and concepts that synergistically supports today’s preventive character of oral care by novel, ecological preventive and therapeutic approaches targeting:
o Modulators of the oral microbiome
o Live biotherapeutics including next generation probiotics
o Pre- and synbiotics
o Phagetherapy
o Active and Passive vaccination
o Host Response modulators
o Antimicrobials & New drug delivery
Furthermore, we also appreciate novel insights into:
• Impact of the immune system in periodontal diseases and dental caries
• Role of the dysbiotic oral microbiome (viriome, mycobiome) including also protozoa and amoeba in oral disease and is spatiotemporal distribution
Type – Original Research, Review, Mini-Review, Clinical study, Perspective
Nevertheless, periodontal disease affects more than 700 million people, making it one of the most prevalent chronic inflammatory diseases worldwide while dental cariogenicity still account as one of the most relevant health disorders in the industrialized world with more than 2 billion cases worldwide. Both diseases cause a tremendous social and economic burden for governmental healthcare systems.
In the last 20 years interruptive scientific advancements in life science and big data paved the road for a richness of detail on various functional levels of biological life. Next generation sequencing allows the insight in polymicrobial communities, inter-microbial and host-microbial interaction beyond community profiling on a yet unseen resolution. In fact, integration of metagenomic and metatranscriptomic data with dysbiotic disease strongly suggests a functional transcriptomic redundancy despite dispersal in the polymicrobial community composition.
In fact, the multifactorial character of oral diseases, strongly insinuated by exogenous parameters and the relevance of the multispecies equilibrium within a phylogenetic ecological framework clearly culminates and integrates the ecological plaque hypothesis with the polymicrobial synergy and dysbiosis model.
Still, even keystone pathogens have their distinct role by driving disease progression. Inflammophilic organisms orchestrate the host immune response, modulating the otherwise pathogen-detrimental inflammatory response to a more dysbiotic-stabilizing, beneficial answer. Certainly, the host immune response from innate defenses to immune tolerance of commensal bacteria contribute as key player to the equilibrium of the oralome and eubiosis.
With this said, we are interested in new insights and concepts that synergistically supports today’s preventive character of oral care by novel, ecological preventive and therapeutic approaches targeting:
o Modulators of the oral microbiome
o Live biotherapeutics including next generation probiotics
o Pre- and synbiotics
o Phagetherapy
o Active and Passive vaccination
o Host Response modulators
o Antimicrobials & New drug delivery
Furthermore, we also appreciate novel insights into:
• Impact of the immune system in periodontal diseases and dental caries
• Role of the dysbiotic oral microbiome (viriome, mycobiome) including also protozoa and amoeba in oral disease and is spatiotemporal distribution
Type – Original Research, Review, Mini-Review, Clinical study, Perspective
Keywords: Oral microbiome, Biotherapeutics, Probiotics, Pre- and synbiotics, Phagetherapy, Antimicrobials
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