About this Research Topic
Nearly 50% of all burns sustained annually involve patients under the age of 18 years, the majority of whom are under the age of 5 years. Since the skin of children is much thinner compared to adults, burn wounds are usually more severe. Especially deep and severe burn wounds have a major impact on the lives of children since these wounds usually result in scar formation. This also applies to other deep wounds, for example caused by accidents or dog bites.
With the currently available treatments, scar formation cannot be completely prevented. Moreover, it is not possible to regenerate skin appendages with these treatments. These appendages, including hair follicles, sweat glands and sebaceous glands, are a major source of stem cells that are involved in wound healing. Knowledge about how these cells are involved in wound healing, together with other molecular mechanisms in this process, will contribute to better treatments with less scarring.
Surgical management plays a crucial role in the comprehensive treatment of pediatric injuries, and the selection of surgical interventions depends on several factors, including the depth, size and location of the wound. Furthermore, the unique anatomic and physiological considerations in pediatric patients require a tailored approach to surgical intervention. Careful attention should be paid to growth potential, scar management and psychological support to minimize long-term consequences and improve quality of life.
In this Research Topic we will focus on the treatment of wounds in children with a specific focus on tissue engineering/regeneration. Topics of interest include:
• Fetal development of skin and skin appendages
• Mechanisms involved in wound healing
• Role of skin appendages in wound healing
• The latest advances in skin tissue engineering
• The latest developments in the field of wound treatments for children
• Advancements in surgical techniques, wound care modalities, and rehabilitation strategies
With the currently available treatments, scar formation cannot be completely prevented. Moreover, it is not possible to regenerate skin appendages with these treatments. These appendages, including hair follicles, sweat glands and sebaceous glands, are a major source of stem cells that are involved in wound healing. Knowledge about how these cells are involved in wound healing, together with other molecular mechanisms in this process, will contribute to better treatments with less scarring.
Surgical management plays a crucial role in the comprehensive treatment of pediatric injuries, and the selection of surgical interventions depends on several factors, including the depth, size and location of the wound. Furthermore, the unique anatomic and physiological considerations in pediatric patients require a tailored approach to surgical intervention. Careful attention should be paid to growth potential, scar management and psychological support to minimize long-term consequences and improve quality of life.
In this Research Topic we will focus on the treatment of wounds in children with a specific focus on tissue engineering/regeneration. Topics of interest include:
• Fetal development of skin and skin appendages
• Mechanisms involved in wound healing
• Role of skin appendages in wound healing
• The latest advances in skin tissue engineering
• The latest developments in the field of wound treatments for children
• Advancements in surgical techniques, wound care modalities, and rehabilitation strategies
Keywords: burn, wounds, tissue regeneration, tissue engineering
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