The third generation of platelet derivatives is called concentrated growth factors (CGFs), it is obtained by centrifuging of whole blood sample using the centrifuge Medifuge MF200. CGF is a denser fibrin matrix containing growth factors, like PDGF, TGF-b1, FGF-2, VEGF, BMP, and platelets, leukocytes, and stem cells. In recent years CGF has been widely used in plastic and reconstructive surgery in dental, dermatological, and orthopedic fields. The use of autologous growth factors and cells in surgical practice avoids immunogenic reactions but above all it improves wound healing, it is involved in inflammation and angiogenesis. Several studies showed the ability of the CGF to facilitate the regeneration of bones, cartilage as well as tendons and ligaments.
There is much evidence of the effectiveness of the CGF applications in inducing cell differentiation and tissue regeneration, however, few studies have focused on the molecular mechanisms activated by platelet derivatives. The effect of CGF in regenerative medicine is mostly attributed to the controlled release of several growth factors, furthermore, the cellular component should be of great importance for stemness characteristics and the differentiation capacity which are poorly investigated. Recent results showed CGF induces the activation of cell signaling pathways involved in cell proliferation, differentiation, and extracellular matrix remodeling.
The low costs and ease of preparation have led to the increasing use of CGF in surgical practice. This requires an in-depth understanding of the mechanisms triggered by this biomaterial in different tissues. The current Research Topic addresses the promising and recent research in molecular mechanisms driven by CGF. We welcome Original Research, Perspective articles, Reviews, or Mini-reviews on one or more of the following themes:
• Characterization of the cellular component of platelet derivatives and their differentiation potential
• Mechanisms involved in tissue regeneration mediated by CGF or other platelet derivatives
• Modulation of activity or level of transcriptional factors that play a key role in cell proliferation or differentiation after CGF treatment
• Application of CGF in regenerative medicine in different surgical practice
• Use of platelet derivatives like bioscaffolds in the regeneration of hard tissues
A full list of accepted article types, including descriptions, can be found at this link.
Keywords:
platelet derivatives, CGF, tissue regeneration, cell differentiation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The third generation of platelet derivatives is called concentrated growth factors (CGFs), it is obtained by centrifuging of whole blood sample using the centrifuge Medifuge MF200. CGF is a denser fibrin matrix containing growth factors, like PDGF, TGF-b1, FGF-2, VEGF, BMP, and platelets, leukocytes, and stem cells. In recent years CGF has been widely used in plastic and reconstructive surgery in dental, dermatological, and orthopedic fields. The use of autologous growth factors and cells in surgical practice avoids immunogenic reactions but above all it improves wound healing, it is involved in inflammation and angiogenesis. Several studies showed the ability of the CGF to facilitate the regeneration of bones, cartilage as well as tendons and ligaments.
There is much evidence of the effectiveness of the CGF applications in inducing cell differentiation and tissue regeneration, however, few studies have focused on the molecular mechanisms activated by platelet derivatives. The effect of CGF in regenerative medicine is mostly attributed to the controlled release of several growth factors, furthermore, the cellular component should be of great importance for stemness characteristics and the differentiation capacity which are poorly investigated. Recent results showed CGF induces the activation of cell signaling pathways involved in cell proliferation, differentiation, and extracellular matrix remodeling.
The low costs and ease of preparation have led to the increasing use of CGF in surgical practice. This requires an in-depth understanding of the mechanisms triggered by this biomaterial in different tissues. The current Research Topic addresses the promising and recent research in molecular mechanisms driven by CGF. We welcome Original Research, Perspective articles, Reviews, or Mini-reviews on one or more of the following themes:
• Characterization of the cellular component of platelet derivatives and their differentiation potential
• Mechanisms involved in tissue regeneration mediated by CGF or other platelet derivatives
• Modulation of activity or level of transcriptional factors that play a key role in cell proliferation or differentiation after CGF treatment
• Application of CGF in regenerative medicine in different surgical practice
• Use of platelet derivatives like bioscaffolds in the regeneration of hard tissues
A full list of accepted article types, including descriptions, can be found at this
link.
Keywords:
platelet derivatives, CGF, tissue regeneration, cell differentiation
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.