About this Research Topic
In this era, where AMR poses a severe threat, discovering new antimicrobials is crucial. This Research Topic aims to delve into the marine environment, a rich source of biodiversity, for novel antimicrobial agents. It focuses on the unique secondary metabolites produced by marine organisms like bacteria, fungi, sponges, tunicates, and algae. These compounds, with their distinct chemical structures and action mechanisms, are key to developing groundbreaking drugs. Our goal is to identify, characterize, and explore the potential of these marine-derived antimicrobials, particularly in combating multidrug-resistant pathogens.
This Research Topic is dedicated to exploring the vast chemical diversity of marine-derived antimicrobials, a key area in Blue Biotechnology. We're looking for detailed studies on isolating, purifying, and structurally analyzing new compounds, using advanced bioassays, and screening techniques. Explorations that use omics approaches, databases, and bioinformatics in discovery process are appealing. Further, we're interested in the chemo- and biosynthesis of these agents, as well as their action mechanisms, understanding their interactions with microbial targets, and how they overcome resistance. Additionally, topics covering pharmacokinetics, in vivo efficacy, sustainable sourcing, and ecological impacts are vital.
Reviews and perspectives on the clinical potential of marine antimicrobials, their comparison with existing antibiotics, and insights into clinical trial strategies are welcomed. We invite a broad range of contributions from marine biology to clinical research.
For the Antimicrobials, Resistance and Chemotherapy section we do not accept:
1. Articles reporting genomic sequence(s) without a substantive biologically relevant functional part.
2. Manuscripts focusing on AMR from an exclusively phenotypic perspective.
3. Clinical studies that do not have parts addressing molecular epidemiology of pathogens and genetic background of AMR.
We welcome all article types allowed in the Antimicrobials, Resistance and Chemotherapy and Marine Biotechnology and Bioproducts sections.
Keywords: multi-drug resistance, microbial biofilms, marine antimicrobials, bioassays, screening techniques and drug discovery
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.