About this Research Topic
Gene expression profiles and changes in brain connectivity are increasingly important in understanding progressive neurodegenerative diseases. These diseases are characterized by progressive neuronal loss and cognitive decline. Recent research has revealed that specific gene expression changes contribute to these conditions, disrupting neural connectivity and brain network integrity. Understanding these molecular and network-level alterations is crucial for developing targeted therapies and diagnostic tools, potentially mitigating the effects of neurodegeneration and improving patient outcomes.
However, the interplay between gene expression and brain connectivity changes remains to be fully elucidated. This research topic aims to address the recent advances in the study of gene expression patterns with the mapping of local and large-scale brain connectivity and the resulting clinical phenotypes. This topic will explore how alterations in gene expression impact the structure and function of brain networks in conditions like Alzheimer's, Parkinson's, and Huntington's disease.
This Research Topic plans to cover manuscripts at the intersection of genetics/proteomics, brain connectivity, and cognitive/behavioral deficits in neurodegenerative diseases, including but not limited to Alzheimer's disease, Parkinson's disease, and Huntington's disease. We welcome Original Research Articles, Reviews, Mini Reviews, Systematic Reviews, Perspectives, Commentaries, Data Notes, and Technical Notes.
Submissions can include, but are not limited to, the following themes:
• Genetic and molecular basis of large-scale network dysfunction and their role in different clinical phenotypes.
• Interplay between genetic/molecular profiles and changes in brain connectivity observed through structural, functional, metabolic, and electrophysiological techniques.
• Human genome variations and susceptibility to brain network dysfunction underlying the early stages of neurodegenerative diseases and/or their progression.
• Link between alterations in brain connectivity and cognitive/behavioral deficits, including impairment of awareness in neurodegenerative diseases.
However, the interplay between gene expression and brain connectivity changes remains to be fully elucidated. This research topic aims to address the recent advances in the study of gene expression patterns with the mapping of local and large-scale brain connectivity and the resulting clinical phenotypes. This topic will explore how alterations in gene expression impact the structure and function of brain networks in conditions like Alzheimer's, Parkinson's, and Huntington's disease.
This Research Topic plans to cover manuscripts at the intersection of genetics/proteomics, brain connectivity, and cognitive/behavioral deficits in neurodegenerative diseases, including but not limited to Alzheimer's disease, Parkinson's disease, and Huntington's disease. We welcome Original Research Articles, Reviews, Mini Reviews, Systematic Reviews, Perspectives, Commentaries, Data Notes, and Technical Notes.
Submissions can include, but are not limited to, the following themes:
• Genetic and molecular basis of large-scale network dysfunction and their role in different clinical phenotypes.
• Interplay between genetic/molecular profiles and changes in brain connectivity observed through structural, functional, metabolic, and electrophysiological techniques.
• Human genome variations and susceptibility to brain network dysfunction underlying the early stages of neurodegenerative diseases and/or their progression.
• Link between alterations in brain connectivity and cognitive/behavioral deficits, including impairment of awareness in neurodegenerative diseases.
Keywords: Neurodegenerative disease, genes, brain networks, connectivity, cognition
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
