About this Research Topic
Trichuris trichiura, colloquially referred to as the whipworm, represents a parasitic nematode species that predominantly parasitizes the large intestine of the human host. Infection occurs following the oral ingestion of fecally contaminated food or water containing the eggs of the parasite. Subsequent to ingestion, the eggs undergo maturation in the small intestine, culminating in the development of larvae within the large intestine. Upon reaching adulthood, the whipworm firmly attaches itself to the mucosal lining of the large intestine, as it sustains itself by feeding on blood. Consequently, infection with Trichuris trichiura may manifest with clinical manifestations characteristic of trichuriasis, including abdominal pain, diarrhea, and anemia.
Mebendazole and albendazole are the predominant pharmacotherapeutic agents employed in the management of trichuriasis. These medications exert their therapeutic effects by targeting and eliminating the mature nematodes residing within the intestinal lumen, thus facilitating the clearance of the parasitic infection. Treatment protocols exhibit variability in duration but commonly entail the administration of the medication over a course of several days to ensure the complete eradication of the parasitic organisms.
Efforts are continuously being made to comprehend the structural features, patho-physiology of trichuriasis and drug modes of action, with the ultimate goal of advancing scientific knowledge for the development of preventive measures and treatment strategies against this disease. The objective of this research topic is to investigate the existing gaps in our understanding of Trichuris trichiura and its significance, thereby facilitating the design of more effective drug therapies and treatment modalities.
We aim to highlight the latest scientific findings on trichuriasis in the following areas:
1. Mode of transmission between the hosts.
2. Pathogenesis and resistance mechanisms developed by the species.
3. Host-pathogen interaction and immune evasion mechanisms.
4. Prevention strategies to stem the infection.
5. Novel treatment strategies against the infection.
This research topic aims to collect various articles on the areas above. We will accept all article types permissible in the Frontiers in Parasitology submission guidelines.
Mebendazole and albendazole are the predominant pharmacotherapeutic agents employed in the management of trichuriasis. These medications exert their therapeutic effects by targeting and eliminating the mature nematodes residing within the intestinal lumen, thus facilitating the clearance of the parasitic infection. Treatment protocols exhibit variability in duration but commonly entail the administration of the medication over a course of several days to ensure the complete eradication of the parasitic organisms.
Efforts are continuously being made to comprehend the structural features, patho-physiology of trichuriasis and drug modes of action, with the ultimate goal of advancing scientific knowledge for the development of preventive measures and treatment strategies against this disease. The objective of this research topic is to investigate the existing gaps in our understanding of Trichuris trichiura and its significance, thereby facilitating the design of more effective drug therapies and treatment modalities.
We aim to highlight the latest scientific findings on trichuriasis in the following areas:
1. Mode of transmission between the hosts.
2. Pathogenesis and resistance mechanisms developed by the species.
3. Host-pathogen interaction and immune evasion mechanisms.
4. Prevention strategies to stem the infection.
5. Novel treatment strategies against the infection.
This research topic aims to collect various articles on the areas above. We will accept all article types permissible in the Frontiers in Parasitology submission guidelines.
Keywords: Trichuris trichiura-Transmission, Pathogenesis, Host-pathogen interaction, Prevention and Treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
