About this Research Topic
The goal of this Research Topic is to investigate the mechanisms and consequences of immune cell exhaustion in cancer therapy, focusing on the tumor microenvironment's role. It aims to explore the functions of specific immune cells, signaling pathways, and transcriptional and metabolic shifts that lead to exhaustion. This initiative seeks to uncover new therapeutic targets and strategies to revitalize exhausted immune cells, thus improving immunotherapy outcomes and providing new hope for cancer patients. Through this, we aspire to bridge basic science with therapeutic advances, facilitating breakthroughs in tackling immune cell exhaustion. We welcome submissions that include but are not limited to the following topics:
1) Cellular and molecular mechanisms of immune cell exhaustion.
2) Exhaustion phenomena in various immune cells (NK cells, B cells, macrophages, etc.) in cancer.
3) Complex networks of immune cell interactions within the tumor microenvironment.
4) Investigating immune cell heterogeneity and states of exhaustion using single-cell sequencing technology.
5) Mapping the spatial distribution of immune cells within the tumor microenvironment using spatial transcriptomics.
6) Novel strategies and therapeutic interventions to reverse exhausted immune cell function.
7) The role and challenges of bioinformatics in elucidating immune cell exhaustion.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Immune Cell Exhaustion, Immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.