About this Research Topic
Acute and chronic lung injuries involve functional abnormalities or structural damage due to conditions like lung infections, sepsis, mechanical ventilation-induced injury, COPD, and pulmonary fibrosis. These injuries are major global health concerns, requiring comprehensive management and early intervention. Understanding their pathophysiology is crucial for developing effective prevention and treatment strategies. However, the specific mechanisms and drug targets remain unclear.
This research topic aims to investigate the mechanisms and therapeutic advancements in acute and chronic lung injuries. The objective is to provide a detailed overview of the molecular mechanisms involved, identify new pharmacological targets, and develop innovative therapies, including nanomedicine. By exploring pathophysiological processes driven by risk factors such as infections and smoking, the study seeks to establish foundations for new drug development and identify potential therapeutic targets.
Contributors should elucidate signaling pathways and molecular networks involved in lung injuries, emphasizing immune cell activation and structural cell damage. They should summarize therapeutic targets and drugs, considering approaches based on cells, genes, proteins, nanomedicine, small molecules, preclinical validation, safety/efficacy studies, and clinical trials.
Contributors are invited to address the following specific themes:
• Molecular Pathways: Elucidating key molecular pathways and interactions among lung cell subpopulations in acute and chronic lung injuries.
• Novel Therapeutic Targets: Identifying promising targets for treating various lung injuries.
• Drug Development and Repurposing: Evaluating the therapeutic effects of candidate drugs for lung injuries.
• Nanomedicine: Developing innovative nanodrugs for respiratory diseases and summarizing the applications of nanomedicine in lung injury treatment.
• Clinical Perspectives: Summarizing clinical observations and proposing potential treatment strategies for lung injuries.
This research topic aims to investigate the mechanisms and therapeutic advancements in acute and chronic lung injuries. The objective is to provide a detailed overview of the molecular mechanisms involved, identify new pharmacological targets, and develop innovative therapies, including nanomedicine. By exploring pathophysiological processes driven by risk factors such as infections and smoking, the study seeks to establish foundations for new drug development and identify potential therapeutic targets.
Contributors should elucidate signaling pathways and molecular networks involved in lung injuries, emphasizing immune cell activation and structural cell damage. They should summarize therapeutic targets and drugs, considering approaches based on cells, genes, proteins, nanomedicine, small molecules, preclinical validation, safety/efficacy studies, and clinical trials.
Contributors are invited to address the following specific themes:
• Molecular Pathways: Elucidating key molecular pathways and interactions among lung cell subpopulations in acute and chronic lung injuries.
• Novel Therapeutic Targets: Identifying promising targets for treating various lung injuries.
• Drug Development and Repurposing: Evaluating the therapeutic effects of candidate drugs for lung injuries.
• Nanomedicine: Developing innovative nanodrugs for respiratory diseases and summarizing the applications of nanomedicine in lung injury treatment.
• Clinical Perspectives: Summarizing clinical observations and proposing potential treatment strategies for lung injuries.
Keywords: Acute lung injury, chronic lung injury, immunity, cell crosstalk, drug targets, nanomedicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
