About this Research Topic
The signaling transduction pathways of innate immunity within the tumor immune microenvironment provide critical insights into the interplay between cancer cells and the host's immune defenses. Innate immune cells, such as macrophages, dendritic cells, and natural killer cells, play pivotal roles in recognizing and responding to tumor cells. These cells are equipped with pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) emitted by stressed or dying tumor cells. Activation of these receptors triggers a cascade of signaling transduction events, leading to the release of cytokines, chemokines, and other mediators that promote inflammation and initiate adaptive immune responses aimed at eliminating the tumor cells.
However, tumors have developed sophisticated mechanisms to evade or subvert these innate immune responses. They can alter the signaling transduction pathways and create an immunosuppressive microenvironment that inhibits effective immune surveillance and the destruction of tumor cells. Understanding the signaling transduction mechanisms of innate immunity and the regulatory processes in the tumor microenvironment is crucial for comprehending cellular interactions, dynamic changes within the tumor microenvironment, and the synergistic functions of immune cells. This knowledge is essential for developing new therapeutic strategies that can enhance the efficacy of the immune system to combat and eliminate cancer cells.
The Research Topic aims to deepen our understanding of the intricate interactions and therapeutic potentials within tumor immunity, aiming to decipher the complex dynamics of the tumor immune microenvironment and to advance more effective cancer immunotherapies, ultimately translating these findings into clinical advancements. Key areas include the following subtopics:
1. Elucidating signaling transduction pathways in innate immune cells within the tumor microenvironment
2. Role of Pattern Recognition Receptors (PRRs) in Tumor Detection and Immune Response
3. Impact of Tumor-Evoked Regulatory Mechanisms on Innate Immunity
4. Interactions Between Innate Immune Cells and the Extracellular Matrix (ECM)
5. Development of Therapeutic Strategies Targeting Innate Immune Signaling
6. Computational Modeling of Innate Immune Signaling in the Tumor Microenvironment
7. Cross-talk Between Innate Immunity and Adaptive Immunity in the Tumor Microenvironment:
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
However, tumors have developed sophisticated mechanisms to evade or subvert these innate immune responses. They can alter the signaling transduction pathways and create an immunosuppressive microenvironment that inhibits effective immune surveillance and the destruction of tumor cells. Understanding the signaling transduction mechanisms of innate immunity and the regulatory processes in the tumor microenvironment is crucial for comprehending cellular interactions, dynamic changes within the tumor microenvironment, and the synergistic functions of immune cells. This knowledge is essential for developing new therapeutic strategies that can enhance the efficacy of the immune system to combat and eliminate cancer cells.
The Research Topic aims to deepen our understanding of the intricate interactions and therapeutic potentials within tumor immunity, aiming to decipher the complex dynamics of the tumor immune microenvironment and to advance more effective cancer immunotherapies, ultimately translating these findings into clinical advancements. Key areas include the following subtopics:
1. Elucidating signaling transduction pathways in innate immune cells within the tumor microenvironment
2. Role of Pattern Recognition Receptors (PRRs) in Tumor Detection and Immune Response
3. Impact of Tumor-Evoked Regulatory Mechanisms on Innate Immunity
4. Interactions Between Innate Immune Cells and the Extracellular Matrix (ECM)
5. Development of Therapeutic Strategies Targeting Innate Immune Signaling
6. Computational Modeling of Innate Immune Signaling in the Tumor Microenvironment
7. Cross-talk Between Innate Immunity and Adaptive Immunity in the Tumor Microenvironment:
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
Keywords: tumor microenvironment, tumor immunity, innate immunity, signaling transduction, target therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
