About this Research Topic
Dysfunction within the musculoskeletal system can lead to various clinical conditions. Innovative solutions are continuously sought after to address these issues. Although implants, prostheses, and biomaterials have been invented and applied in clinical practice to reconstruct musculoskeletal structures, limitations such as inadequate natural regeneration persist. To address these issues, it is essential to have a thorough understanding of the complex relationship between cells and materials and to precisely manipulate their interactions. This is crucial for the advancement of next-generation implants and biomaterials. By utilizing these means, it may be possible to bridge the gap between biological intricacies and material design, resulting in the development of more effective and biocompatible solutions for enhanced musculoskeletal reconstruction and improved patient outcomes.
This topic aims to investigate and explain the interactions between cells and materials on a micro-scale after implantation. This will provide new insights into the treatment of musculoskeletal disorders and contribute to the advancement of orthopedics and regenerative medicine. The recent advancements in biomaterials that have shown promising results in facilitating disease treatment and promoting natural or effective regeneration will be reported, and these innovative approaches such as tailoring the proper microenvironment, regulating intracellular crosstalk, manipulating cell-material interactions, and directing cell fate, will be comprehensively discussed.
This research topic concentrates predominantly on the elucidation and manipulation of cell-material interactions, and novel biomaterials that have shown promising results in tissue regeneration via such means, though its scope isn't solely restricted to these. We welcome and encourage the submission of studies on musculoskeletal system disorders treatment with specific biomaterials interventions. Topics of interest include, but are not limited to, the following aspects:
• Novel implants, prosthesis modification methods, and biomaterials show promising and effective reconstruction potential in bone, cartilage, muscle, nerve, etc. related disorders.
• The manipulation of the cell-implant microenvironment, including immunogenic responses, intracellular crosstalk, cell differentiation and fate, and senescence, can be achieved using bioactive materials.
This topic aims to investigate and explain the interactions between cells and materials on a micro-scale after implantation. This will provide new insights into the treatment of musculoskeletal disorders and contribute to the advancement of orthopedics and regenerative medicine. The recent advancements in biomaterials that have shown promising results in facilitating disease treatment and promoting natural or effective regeneration will be reported, and these innovative approaches such as tailoring the proper microenvironment, regulating intracellular crosstalk, manipulating cell-material interactions, and directing cell fate, will be comprehensively discussed.
This research topic concentrates predominantly on the elucidation and manipulation of cell-material interactions, and novel biomaterials that have shown promising results in tissue regeneration via such means, though its scope isn't solely restricted to these. We welcome and encourage the submission of studies on musculoskeletal system disorders treatment with specific biomaterials interventions. Topics of interest include, but are not limited to, the following aspects:
• Novel implants, prosthesis modification methods, and biomaterials show promising and effective reconstruction potential in bone, cartilage, muscle, nerve, etc. related disorders.
• The manipulation of the cell-implant microenvironment, including immunogenic responses, intracellular crosstalk, cell differentiation and fate, and senescence, can be achieved using bioactive materials.
Keywords: Microenvironment, bone, cartilage, muscle, nerve, biomaterial, cell-material interaction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
