About this Research Topic
DNA damage and the disorder of the repair system in somatic cells is the root cause of cancer. On the contrary, the genome stability of tumor cells is also a primary reason why many chemotherapy drugs struggle to kill them. Although oncology research has continued for hundreds of years, and the study of tumor proliferation and apoptosis is still hot today. People have started to stop keeping an eye on the tumor in isolation but focus on the extracellular cell communications among cancer and the surrounding blood vessels, nerves, fibroblasts, adipocyte, and immune cell populations, termed as tumor microenvironment. Tumor metastasis and immunotherapy therefore have become one of the main topics in cancer research. The link between DNA damage and tumor cell communication will span the cell regulation process of multiple dimensions, which is of great significance for the systematic and comprehensive understanding of tumor occurrence and progression. It also provides new thinking for the innovation and improvement of treatment strategy.
This Research Topic aims to connect the regulation of DNA damage and repair system with extracellular communications in the microenvironment, and attempts to address two questions: 1) the changes in the tumor microenvironment caused by DNA damage, and 2) the effects of the microenvironment on tumor genome stability.
We welcome submissions focus on, but not limited to, the following subtopics:
• Changes in the tumor microenvironment caused by DNA damage, genomic instability, chromatin crosslinking, or three-dimensional structure alteration of chromatin
• The effect of the deficiency or dysfunction of DNA repair systems and the resulting cell cycle disruption on the response of tumor cells to external stimuli
• Effects of chemotherapy, radiotherapy, immunotherapy, and newly developed small molecule drugs on genomic stability of tumor cells
• Effects of exosomes, chemokines, and cytokines from the microenvironment on tumor genome stability
This Research Topic aims to connect the regulation of DNA damage and repair system with extracellular communications in the microenvironment, and attempts to address two questions: 1) the changes in the tumor microenvironment caused by DNA damage, and 2) the effects of the microenvironment on tumor genome stability.
We welcome submissions focus on, but not limited to, the following subtopics:
• Changes in the tumor microenvironment caused by DNA damage, genomic instability, chromatin crosslinking, or three-dimensional structure alteration of chromatin
• The effect of the deficiency or dysfunction of DNA repair systems and the resulting cell cycle disruption on the response of tumor cells to external stimuli
• Effects of chemotherapy, radiotherapy, immunotherapy, and newly developed small molecule drugs on genomic stability of tumor cells
• Effects of exosomes, chemokines, and cytokines from the microenvironment on tumor genome stability
Keywords: cancer, DNA damage, genome stabilization, microenvironment, intercellular communication
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
