About this Research Topic
The mechanisms of interaction between stromal and epithelial cells are poorly described in PCa. However, evidence suggests that stromal cells can contribute significantly to castration-resistant prostate cancer (CRPC). The tumor/stroma ratio and the expression of stromal markers represent a possible prognostic tool in determining PCa progression and predicting therapeutic response. In contrast, testicular germ cell tumors (TGCTs) are rare form of cancers that generally occur in childhood and early stages of adulthood, but in most cases, TGCT are a curable cancer. Therefore, its incidence has been increasing and there is a major attention on the study of the molecular pathway of this tumor. Recently, in vitro and in vivo studies are focusing on the molecular pathways and epigenetic mechanisms of TGCTs. These studies aim to develop new therapeutic approaches and identify new potential epigenetic biomarkers, thus providing powerful prognostic and diagnostic tools.
This Research Topics welcomes submissions of Original Research, Brief Research Reports, Reviews, Mini-reviews, Methods, Perspectives, and Opinion articles focused, but not limited, to the following subtopics:
• Identification of novel biomarkers for prostate and testicular cancers prognosis;
• Experimental validation of epigenetic biomarkers for prostate and testicular tumors;
• New therapeutic approaches for prostate and testicular tumors (natural bioactive molecules, hormone therapy for prostate cancer);
• Identification of genes involved in tumor progression and/or other signalling pathways.
Keywords: Biomarkers, prostate cancer, testicular cancer, cellular strategies, cell-based strategies
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