About this Research Topic
Astrocytes are the most abundant type of specialized glial cells in the central nervous system (CNS). They can assist neurons in maintaining CNS homeostasis. After CNS injury, astrocytes become “reactive” and the most important component within and around the lesion site. Increasing evidence suggests that astrocytes exert both beneficial and detrimental effects on neurons after CNS injury. The interactions of reactive astrocytes with neurons strongly influence the process of CNS injury repair. Investigating the intrinsic mechanisms that regulate neurotoxic versus neuroprotective astrocyte and their effects on astrocyte-neuron interaction is crucial to improving the treatment outcome of CNS injury. Some studies have been performed to understand the function of astrocyte-neuron interaction. However, its detailed regulatory mechanisms remain to be determined.
Understanding the molecular and cellular pathways that regulate the balance of protective and harmful astrocyte reactivity remains a major goal in basic and translational neuroscience. Investigating the function and mechanisms of astrocytes is crucial to improving the treatment outcome of CNS injury. Here, we invite experts in both fields of astrocyte and neuron to show their findings, which range from the function detection and regulatory mechanisms analysis related to CNS injury, including traumatic brain injury and spinal cord injury. It is necessary to explore and elucidate the function and mechanisms regarding astrocyte phenotypic transformation and astrocyte-neuron interaction, as it may serve as a target for the effective treatment of CNS injury.
Scope and Information for authors:
1. The function and mechanisms regarding astrocytes phenotypic transformation in CNS injury.
2. Interaction between astrocytes and neurons and its regulatory mechanisms.
3. The mechanism of neurological recovery after CNS injury, including axon growth, synaptogenesis, and synaptic pruning.
Understanding the molecular and cellular pathways that regulate the balance of protective and harmful astrocyte reactivity remains a major goal in basic and translational neuroscience. Investigating the function and mechanisms of astrocytes is crucial to improving the treatment outcome of CNS injury. Here, we invite experts in both fields of astrocyte and neuron to show their findings, which range from the function detection and regulatory mechanisms analysis related to CNS injury, including traumatic brain injury and spinal cord injury. It is necessary to explore and elucidate the function and mechanisms regarding astrocyte phenotypic transformation and astrocyte-neuron interaction, as it may serve as a target for the effective treatment of CNS injury.
Scope and Information for authors:
1. The function and mechanisms regarding astrocytes phenotypic transformation in CNS injury.
2. Interaction between astrocytes and neurons and its regulatory mechanisms.
3. The mechanism of neurological recovery after CNS injury, including axon growth, synaptogenesis, and synaptic pruning.
Keywords: Glial cells, Astrocytes, Neuron, Central Nervous System Injury
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