About this Research Topic
Antimicrobial resistance (AMR) has become a persistent global public health crisis, with an alarming projection of 10 million annual deaths worldwide by 2050. The primary driver of this crisis is the widespread misuse and overuse of antimicrobials, particularly antibiotics, intensifying the global burden of resistance. To address this, global antibiotic consumption is rigorously monitored. The "One Health Approach"; emphasizing a multidisciplinary effort that recognizes the interconnectedness of human, animal, and environmental health, is crucial. Despite these efforts, the importance of enhancing public awareness and health literacy, integral to both global and local action plans, remains paramount. AMR reflects a complex interplay of factors, encompassing social anthropology, civil unrest, diasporas, political systems, healthcare, economics, societal behavior, health literacy, geoclimatic events, global travel, and pharmaceutical innovation. Effectively addressing AMR necessitates a comprehensive solution that navigates these intricate dynamics to mitigate further emergence. In essence, AMR poses a multifaceted 21st-century global public health dilemma, demanding a nuanced and integrated approach for sustainable solutions.
The global health landscape is under severe threat from AMR, rendering traditional medicines ineffective and escalating the prevalence of incurable diseases. To confront this escalating challenge, innovative methodologies are imperative, given that bacteria and other pathogens continuously evolve to withstand conventional therapeutic approaches. Addressing the menace of AMR and other detrimental illnesses necessitates the application of gene editing technologies, such as CRISPR-Cas9. The prevailing concern revolves around the urgent requirement for targeted and efficient approaches to counter antibiotic resistance. Traditional treatments often lack precision, inadvertently harming beneficial bacteria and fostering resistance development. By leveraging the precise modification of bacterial genomes facilitated by gene editing, it becomes feasible to disrupt resistance mechanisms and reinstate antibiotic sensitivity.
This technology also creates opportunities for the exploration of entirely novel treatment modalities, including the creation of synthetic antibacterial agents. Recent developments in gene editing have shown previously unheard-of accuracy and effectiveness. Using CRISPR-based technologies, scientists can introduce alterations that impede resistance processes or inactivate particular genes linked to resistance. By reducing off-target effects, this strategy improves the safety and effectiveness of therapies. Additionally, CRISPR systems can be tailored to combat various infections, offering a versatile treatment for a spectrum of infectious diseases. In conclusion, gene editing technologies present an advanced solution to challenges related to pathogenicity and antibiotic resistance. These instruments have the capacity to completely transform the field of treating infectious diseases by making precise and focused changes, serving as an efficient strategy to safeguard global health.
This Research Topic endeavors to explore diverse strategies involving gene editing technologies to tackle antibiotic resistance. By spotlighting the constraints of traditional therapeutic methods, our objective is to underscore the significance of gene editing techniques in addressing the evolving challenges in healthcare especially AMR and other pathogenic diseases. The emphasis will be on advocating for a multidisciplinary approach that acknowledges the interconnected nature of these issues, with a particular focus on enhancing public awareness and health literacy through the efficient research articles. This approach is pivotal for the success of both global and local action plans in combatting antibiotic resistance.
In conclusion, creative approaches are needed to combat the growing issue of AMR, and gene editing technologies appear to be a viable one. Targeted tactics against antibiotic resistance are made possible by the precision with which CRISPR-Cas9 modifies bacterial genomes. This cutting-edge strategy offers a thorough solution to the intricate global health issues raised by AMR, especially when combined with a multidisciplinary "One Health" viewpoint and increased public awareness. The estimated 10 million fatalities annually by 2050 underline the importance of these efforts and the urgent need for coordinated, multifaceted action.
The research articles should be based on, but not limited to, below titles:
- Research articles focusing on recent advancements in gene editing strategies considering pathogens and related AMR in humans, animals and plants.
- Research articles focusing on CRISPR-Cas systems targeting AMR genes.
- Research articles focusing on gene editing strategies including CRISPR-Cas systems against emerging pathogens in different hosts.
- Research articles focusing on novel approaches in combating AMR.
- Research articles focusing on interdisciplinary tactics: Incorporating Gene Editing within the framework of One Health Strategies.
The global health landscape is under severe threat from AMR, rendering traditional medicines ineffective and escalating the prevalence of incurable diseases. To confront this escalating challenge, innovative methodologies are imperative, given that bacteria and other pathogens continuously evolve to withstand conventional therapeutic approaches. Addressing the menace of AMR and other detrimental illnesses necessitates the application of gene editing technologies, such as CRISPR-Cas9. The prevailing concern revolves around the urgent requirement for targeted and efficient approaches to counter antibiotic resistance. Traditional treatments often lack precision, inadvertently harming beneficial bacteria and fostering resistance development. By leveraging the precise modification of bacterial genomes facilitated by gene editing, it becomes feasible to disrupt resistance mechanisms and reinstate antibiotic sensitivity.
This technology also creates opportunities for the exploration of entirely novel treatment modalities, including the creation of synthetic antibacterial agents. Recent developments in gene editing have shown previously unheard-of accuracy and effectiveness. Using CRISPR-based technologies, scientists can introduce alterations that impede resistance processes or inactivate particular genes linked to resistance. By reducing off-target effects, this strategy improves the safety and effectiveness of therapies. Additionally, CRISPR systems can be tailored to combat various infections, offering a versatile treatment for a spectrum of infectious diseases. In conclusion, gene editing technologies present an advanced solution to challenges related to pathogenicity and antibiotic resistance. These instruments have the capacity to completely transform the field of treating infectious diseases by making precise and focused changes, serving as an efficient strategy to safeguard global health.
This Research Topic endeavors to explore diverse strategies involving gene editing technologies to tackle antibiotic resistance. By spotlighting the constraints of traditional therapeutic methods, our objective is to underscore the significance of gene editing techniques in addressing the evolving challenges in healthcare especially AMR and other pathogenic diseases. The emphasis will be on advocating for a multidisciplinary approach that acknowledges the interconnected nature of these issues, with a particular focus on enhancing public awareness and health literacy through the efficient research articles. This approach is pivotal for the success of both global and local action plans in combatting antibiotic resistance.
In conclusion, creative approaches are needed to combat the growing issue of AMR, and gene editing technologies appear to be a viable one. Targeted tactics against antibiotic resistance are made possible by the precision with which CRISPR-Cas9 modifies bacterial genomes. This cutting-edge strategy offers a thorough solution to the intricate global health issues raised by AMR, especially when combined with a multidisciplinary "One Health" viewpoint and increased public awareness. The estimated 10 million fatalities annually by 2050 underline the importance of these efforts and the urgent need for coordinated, multifaceted action.
The research articles should be based on, but not limited to, below titles:
- Research articles focusing on recent advancements in gene editing strategies considering pathogens and related AMR in humans, animals and plants.
- Research articles focusing on CRISPR-Cas systems targeting AMR genes.
- Research articles focusing on gene editing strategies including CRISPR-Cas systems against emerging pathogens in different hosts.
- Research articles focusing on novel approaches in combating AMR.
- Research articles focusing on interdisciplinary tactics: Incorporating Gene Editing within the framework of One Health Strategies.
Keywords: antimicrobial resistance, gene editing, CRISPR-Cas systems, pathogens, one health approach
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
