About this Research Topic
Lipids play a crucial role in endocrinology, influencing hormonal regulation and contributing to various physiological processes. Lipids are essential for the synthesis of steroid hormones, which include hormones such as cortisol, aldosterone, and sex hormones (estrogen, progesterone, testosterone). Steroid hormones are derived from cholesterol, a type of lipid. Lipids, therefore, serve as precursors to produce these critical signaling molecules. Lipids are also essential for cell structure and cell signaling including endocrine signaling for hormonal activity.
Disorders of lipid metabolism are often associated with endocrine-related diseases. For example, dyslipidemia, characterized by abnormal lipid levels in the blood, is a common feature of conditions like diabetes and metabolic syndrome. Lipids contribute to the pathophysiology of these diseases, influencing insulin resistance, inflammation, and cardiovascular risk. Lipids play a role in the transport of lipophilic (lipid-soluble) hormones through the bloodstream. Lipophilic hormones, such as thyroid hormones and steroid hormones, require carrier proteins that are often lipid-based for their transport.
Understanding the intricate relationship between lipids and endocrinology is essential for unraveling the complexities of hormonal regulation, metabolic homeostasis, and the pathophysiology of endocrine-related diseases. Research in this area contributes to advancements in the diagnosis and treatment of conditions such as diabetes, obesity, thyroid, and cardiovascular diseases, and guides the development of novel therapeutic strategies.
This Research Topic seeks to bring together cutting-edge research that addresses the multifaceted relationships between endocrinology, lipids, and the initiation or progression of diseases. Lipid alterations/abnormalities are known to contribute various endocrinopathies such as acromegaly, hypothyroidism, PCOS, premature cardiovascular atherosclerosis, Type II diabetes, inflammations etc. This novel approach will introduce the innovative concept of lipocrinology, which promises to bring a new perspective to lipidology and endocrinology. The goal is to inspire clinicians and researchers to better understand the complex connections between hormones and lipids.
Topics of interest include but are not limited to:
1. Lipids as Signaling Molecules:
- Exploring the signaling pathways through which lipids influence endocrine function.
- Unraveling the molecular mechanisms by which lipid signaling contributes to disease pathogenesis.
2. Endocrine Disorders and Lipid Abnormalities
- Examining the link between endocrine disorders (e.g., diabetes, thyroid dysfunction) and lipid profile alterations.
- Identifying potential therapeutic targets for mitigating endocrine-related lipid abnormalities.
3. Metabolic Syndrome and Cardiovascular Complications:
- Investigating the intersection between endocrine dysregulation, lipid abnormalities, and the development of metabolic syndrome.
- Assessing the impact of these factors on cardiovascular health.
4. Precision Medicine Approaches:
- Highlighting personalized interventions based on the understanding of individualized endocrine and lipid profiles.
- Showcasing advancements in precision medicine for managing diseases at the intersection of endocrinology and lipid metabolism.
5. Endocrine activity of fat in the concert of organ-cross talk and clinical complications of obesity.
6. Altered fat distribution as a cause of fatty liver disease
-Intracardial fat accumulation as a clue for improving cardiovascular risk including atrial fibrillation and heart failure.
This Research Topic aims to attract high-quality contributions from researchers and experts in the field. The Editors welcome original research articles, reviews, and perspectives that advance our understanding of how endocrine and lipid interactions contribute to the onset and progression of diseases.
Disorders of lipid metabolism are often associated with endocrine-related diseases. For example, dyslipidemia, characterized by abnormal lipid levels in the blood, is a common feature of conditions like diabetes and metabolic syndrome. Lipids contribute to the pathophysiology of these diseases, influencing insulin resistance, inflammation, and cardiovascular risk. Lipids play a role in the transport of lipophilic (lipid-soluble) hormones through the bloodstream. Lipophilic hormones, such as thyroid hormones and steroid hormones, require carrier proteins that are often lipid-based for their transport.
Understanding the intricate relationship between lipids and endocrinology is essential for unraveling the complexities of hormonal regulation, metabolic homeostasis, and the pathophysiology of endocrine-related diseases. Research in this area contributes to advancements in the diagnosis and treatment of conditions such as diabetes, obesity, thyroid, and cardiovascular diseases, and guides the development of novel therapeutic strategies.
This Research Topic seeks to bring together cutting-edge research that addresses the multifaceted relationships between endocrinology, lipids, and the initiation or progression of diseases. Lipid alterations/abnormalities are known to contribute various endocrinopathies such as acromegaly, hypothyroidism, PCOS, premature cardiovascular atherosclerosis, Type II diabetes, inflammations etc. This novel approach will introduce the innovative concept of lipocrinology, which promises to bring a new perspective to lipidology and endocrinology. The goal is to inspire clinicians and researchers to better understand the complex connections between hormones and lipids.
Topics of interest include but are not limited to:
1. Lipids as Signaling Molecules:
- Exploring the signaling pathways through which lipids influence endocrine function.
- Unraveling the molecular mechanisms by which lipid signaling contributes to disease pathogenesis.
2. Endocrine Disorders and Lipid Abnormalities
- Examining the link between endocrine disorders (e.g., diabetes, thyroid dysfunction) and lipid profile alterations.
- Identifying potential therapeutic targets for mitigating endocrine-related lipid abnormalities.
3. Metabolic Syndrome and Cardiovascular Complications:
- Investigating the intersection between endocrine dysregulation, lipid abnormalities, and the development of metabolic syndrome.
- Assessing the impact of these factors on cardiovascular health.
4. Precision Medicine Approaches:
- Highlighting personalized interventions based on the understanding of individualized endocrine and lipid profiles.
- Showcasing advancements in precision medicine for managing diseases at the intersection of endocrinology and lipid metabolism.
5. Endocrine activity of fat in the concert of organ-cross talk and clinical complications of obesity.
6. Altered fat distribution as a cause of fatty liver disease
-Intracardial fat accumulation as a clue for improving cardiovascular risk including atrial fibrillation and heart failure.
This Research Topic aims to attract high-quality contributions from researchers and experts in the field. The Editors welcome original research articles, reviews, and perspectives that advance our understanding of how endocrine and lipid interactions contribute to the onset and progression of diseases.
Keywords: Phospholipids, Hormones, Endocrinology, Cholesterol, endocrinopathies
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