About this Research Topic

Background

The field of medicinal chemistry has seen remarkable progress in recent years, particularly in the design and synthesis of bioactive compounds. Among these, sulfonamides and their bioisosteres have gained significant attention due to their diverse therapeutic applications. Sulfonamide derivatives exhibit a broad spectrum of biological activities, making them promising candidates for drug development. The exploration of novel pathways and understanding their mechanisms of action are critical steps towards harnessing their full therapeutic potential.

This Research Topic aims to address the evolving landscape of bioactive sulfonamides and their bioisosteres by delving into recent advances in design, synthesis, and therapeutic applications. The goal is to present a comprehensive overview of the current state of knowledge in this field, identify existing challenges, and propose potential avenues for future research. By highlighting innovative synthetic strategies, structural insights, and mechanistic studies, we seek to foster a deeper understanding of these compounds for enhanced therapeutic interventions. Recent advancements in medicinal chemistry have opened up new possibilities for optimizing bioactivity through the concept of bioisosterism. This Research Topic will explore how bioisosterism can be leveraged to design and synthesize sulfonamide derivatives with improved pharmacological profiles. The scope extends to investigating the therapeutic applications of sulfonamides in various diseases, providing a platform for researchers to showcase their findings and contribute to the collective knowledge in this field. Contributors are encouraged to provide insights into the latest developments, challenges, and future directions within these themes. This Research Topic aspires to be a valuable resource for researchers, professionals, and academicians by offering a comprehensive overview of the field and promoting further advancements in the exploration of bioactive sulfonamides and their bioisosteres.

We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthetic Strategies: Innovative methodologies for synthesizing and designing bioactive sulfonamides and their bioisosteres.
• Structural Insights: Investigation into the structural aspects of sulfonamide derivatives and their correlation with biological activities.
• Mechanistic Studies: Understanding the mechanisms of action underlying the bioactivity of sulfonamides.
• Therapeutic Applications: Exploration of the therapeutic potential of sulfonamide derivatives across various diseases.
• Bioisosterism: Examination of the concept of bioisosterism in optimizing the bioactivity of sulfonamide compounds.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• Mini Review
• Original Research
• Perspective
• Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• Mini Review
• Original Research
• Perspective
• Review

Keywords: Synthetic Methodologies, Structural Insights, Bioactive Sulfonamides, Bioisosterism, Therapeutic Potential

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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