Exploring the Cytoskeletal Regulation of Cellular Metabolism and Disease Progression

The cytoskeleton, particularly the actomyosin network, is integral not only in maintaining cellular structure but also in regulating the spatial and temporal dynamics of metabolic functions and disease progression. By coordinating the signaling networks that influence membrane dynamics, the cytoskeleton directly impacts cellular behavior and bioenergetics. This regulation is crucial for cellular adaptation to environmental stimuli and maintenance of homeostasis. However, disruptions in these processes can lead to metabolic dysfunctions and disease. There is a growing recognition of the need to better understand these interactions, as they hold the key to unlocking new therapeutic strategies targeting these underlying mechanisms.

This Research Topic aims to illuminate the intricate mechanisms by which the cytoskeletal networks, with a focus on the actomyosin cytoskeleton, influence cellular metabolism and propel disease processes through their control of spatial and temporal dynamics. This inquiry is vital to bridge significant knowledge gaps regarding the interaction between cytoskeletal architecture and metabolic signaling. Through leveraging state-of-the-art imaging, molecular biology, and bioinformatics tools, this research will parse out how alterations in cytoskeletal organization affect signaling pathways and metabolic functions, potentially leading to innovative treatments for diseases linked to cytoskeletal and metabolic dysfunction.

In pursuit of comprehensive insights into the regulatory roles of cytoskeletal networks, this Research Topic is specifically oriented towards:

-Dynamics of actomyosin networks in metabolic regulation and energy efficiency

-Cross-talk between cytoskeletal components and metabolic pathways influencing disease

-Impact of cytoskeletal disruptions on disease mechanisms and pathology

-Advanced technologies and methodologies for studying cytoskeletal and metabolic interactions

Encompassing a range of disciplines, this topic encourages collaborative and interdisciplinary research approaches. Contributions may include empirical research providing new data, theoretical analyses that frame future research directions, or comprehensive reviews that consolidate current knowledge in the field. Ultimately, this Research Topic seeks to pave the way for novel therapeutic avenues by enhancing the understanding of how cytoskeletal and metabolic pathways intersect in the context of health and disease.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Actomyosin Cytoskeleton, Signaling Networks, Membrane Dynamics, Spatiotemporal Regulation, Metabolism, Energy Production, Bioenergetics, Disease Progression

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.