About this Research Topic
In this Research Topic, we welcome submissions of original research articles, reviews, clinical trials, translational studies, and perspectives that contribute to our understanding of how radiotherapy-based treatments organize the TME metabolism, with a focus on translating findings from pre-clinical models to clinical practice.
This Research Topic invites contributions that investigate the effects of radiotherapy on the TME metabolism across the translational spectrum. Subtopics of interest include, but are not limited to:
1. Pre-clinical models like 2D models and 3D models for studying radiotherapy-induced metabolic changes in the TME.
2. Mechanistic insights into the role of radiotherapy-related metabolic change in modulating immune responses, angiogenesis, and stromal components in TME.
3. Clinical imaging techniques for assessing radiotherapy-induced alterations in the TME.
4. Biomarkers predictive of TME metabolism response to radiotherapy-based treatments.
5. Clinical trials evaluating novel radiotherapy strategies targeting the TME metabolism.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: novel therapeutic strategies, immune cells, immunosuppressive factors, molecular mechanisms of resistance
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.