About this Research Topic
Cell death is a fundamental physiological process crucial for maintaining biological homeostasis. Its roles range from host defense against pathogens and the regulation of tissue growth to the orchestration of immune responses. Recent studies have begun to unravel the molecular mechanisms of programmed cell death in the pathogenic progression of kidney disease. Indeed, forms of cell death, including necroptosis and pyroptosis, may play pathological roles in various kidney diseases due to the recruitment of immune cells. Thus, cell death patterns have emerged as an innovative therapeutic target for kidney disease. Importantly, the varied interconnected pathways regulating cell death also present challenges and opportunities for further exploration of kidney disease's pathogenesis and pharmaceutical intervention.
Cell death comprises multiple formats; ongoing studies have identified several key players involved in these processes, with the immune system possibly playing a central role. However, the precise mechanisms of action need additional investigation. This RT aims to explore the role of cell death in kidney diseases' evolution and the impact of pharmaceutical treatment on cell death and immune cells, thereby offering a platform for unearthing potential and effective therapeutic targets.
In kidney diseases such as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD), the manipulation of cell death can open up potential therapeutic pathways. These might encompass either the prevention of unwanted cell death or the promotion of cell death in specific cell types. We encourage and welcome submissions of original research and review papers specifically related to, but not limited to, the following topics:
• Relationships between cell death pathways and immune-related nephropathy.
• Novel biomarkers of distinct types of regulated necrosis in hypertensive nephropathy.
• Innovative non-conventional therapies demonstrating efficacy in membranous nephropathy by regulating cell death.
• Impact of pharmaceutical compounds on cell death during the onset of kidney diseases.
• The influence of immunity and inflammation on cell death in kidney diseases.
Cell death comprises multiple formats; ongoing studies have identified several key players involved in these processes, with the immune system possibly playing a central role. However, the precise mechanisms of action need additional investigation. This RT aims to explore the role of cell death in kidney diseases' evolution and the impact of pharmaceutical treatment on cell death and immune cells, thereby offering a platform for unearthing potential and effective therapeutic targets.
In kidney diseases such as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD), the manipulation of cell death can open up potential therapeutic pathways. These might encompass either the prevention of unwanted cell death or the promotion of cell death in specific cell types. We encourage and welcome submissions of original research and review papers specifically related to, but not limited to, the following topics:
• Relationships between cell death pathways and immune-related nephropathy.
• Novel biomarkers of distinct types of regulated necrosis in hypertensive nephropathy.
• Innovative non-conventional therapies demonstrating efficacy in membranous nephropathy by regulating cell death.
• Impact of pharmaceutical compounds on cell death during the onset of kidney diseases.
• The influence of immunity and inflammation on cell death in kidney diseases.
Keywords: Programmed cell death; cell death mechanisms;
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
