Regenerative Liver Surgery

Liver resection is the only curative therapy for both primary and secondary liver tumors. The ability of the liver to regenerate allows safe resection, especially when the malignancy is limited to a single liver lobe. However, in cases of bilobar disease, resection may not be an option due to inadequate future liver remnant. Consequently, methods of liver hypertrophy induction were developed. The era of liver regenerative surgery started with portal vein embolization and at this moment it ends with liver venous deprivation. Other methods include ALPPS (associated liver partition and portal vein ligation for staged hepatectomy), two-stage hepatectomy, hepatic artery/vein embolization, and parenchyma-sparing hepatectomy. Promoting postoperative liver regeneration is important in liver transplantation as well, and various methods using machine perfusion or intensive care measures were developed to address this problem. Due to the number and complexity of these methods, proper scientific and clinical evaluation is imperative. Such studies are required to evaluate the safety and feasibility of the methods as well as long-term oncologic results.

This Research Topic aims to provide a comprehensive overview of the latest advancements in hepatobiliary surgery especially those related to liver regenerative surgery. It focuses on current trends and future directions in the field of liver surgery, but also on fundamental and translational research on liver regeneration. Such studies would definitely contribute to the understanding of postoperative regeneration mechanisms which are currently poorly understood.

We welcome all types of article formats including Original research, Comments, Systematic Reviews, or Short Reports covering, but not limited to, the following subtopics:

-Methods for liver hypertrophy promotion
-Postoperative liver failure
-State-of-the-art Techniques in modern liver surgery
-Basic mechanisms of liver regeneration
-Preoperative factors affecting liver regeneration
-Liver transplantation

Keywords: Liver, Regeneration, Hypertrophy, Surgery, Regenerative Surgery, Visceral Surgery

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.