About this Research Topic
Myeloid cells play crucial roles in both physiological and pathological states, adapting dynamically to changes within the body's microenvironment. Recent research has extensively explored the functional heterogeneity and plasticity of these cells, particularly through advanced technologies like single-cell analytics and flow cytometry. Notably, myeloid cells have shown promising therapeutic possibilities, such as targeting specific subsets or using them as vehicles for drug delivery in conditions including cancer, infectious diseases, and autoimmune disorders. Despite these advancements, there remain significant gaps in our understanding of myeloid cell behavior across various disease states.
This Research Topic aims to synthesize the latest developments and foster discussions among scientists and clinicians on the adaptive mechanisms of myeloid cells in response to environmental cues, particularly inflammation and stress-induced hematopoiesis. The focus will be on understanding the pathways influencing myeloid differentiation and activation, and examining how these processes contribute to disease pathogenesis, especially in the contexts of malignancy and immune suppression.
To gather further insights into myeloid cell dynamics we welcome submissions related but not limited to the following:
o Phenotypic plasticity and heterogeneity of myeloid cells
o Interactions between bone marrow and myeloid lineages
o Mechanisms of differentiation during stress hematopoiesis
o Roles within the tumor microenvironment and inflammatory states
o Redox mechanisms contributing to inflammatory diseases
o Unique features and responses of myeloid cells in various diseases
o Receptor expression and signaling pathways in disease contexts
o Therapeutic strategies targeting, or utilizing, myeloid cells
We invite contributions encompassing original research, reviews, and more, to deepen our understanding and explore new frontiers in myeloid cell research. A full list of accepted article types, including descriptions, can be found at this link.
This Research Topic aims to synthesize the latest developments and foster discussions among scientists and clinicians on the adaptive mechanisms of myeloid cells in response to environmental cues, particularly inflammation and stress-induced hematopoiesis. The focus will be on understanding the pathways influencing myeloid differentiation and activation, and examining how these processes contribute to disease pathogenesis, especially in the contexts of malignancy and immune suppression.
To gather further insights into myeloid cell dynamics we welcome submissions related but not limited to the following:
o Phenotypic plasticity and heterogeneity of myeloid cells
o Interactions between bone marrow and myeloid lineages
o Mechanisms of differentiation during stress hematopoiesis
o Roles within the tumor microenvironment and inflammatory states
o Redox mechanisms contributing to inflammatory diseases
o Unique features and responses of myeloid cells in various diseases
o Receptor expression and signaling pathways in disease contexts
o Therapeutic strategies targeting, or utilizing, myeloid cells
We invite contributions encompassing original research, reviews, and more, to deepen our understanding and explore new frontiers in myeloid cell research. A full list of accepted article types, including descriptions, can be found at this link.
Keywords: myeloid cell line, neutrophils, macrophages, cellular plasticity, myeloid derived suppressor cells, chronic inflammation, cancer, innate immunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
