About this Research Topic
The field of oxidative stress and its role in the pathogenesis of various diseases has garnered significant attention in recent years. Overproduction of reactive oxygen species (ROS) is implicated in conditions such as cancer, insulin resistance, diabetes mellitus, cardiovascular diseases, and atherosclerosis. Despite numerous attempts to mitigate these conditions using antioxidants, the results have been inconsistent, leading to ongoing debates within the scientific community. Initial therapeutic approaches focused on non-enzymatic antioxidants, but these were often ineffective due to unclear targeting of specific ROS. Recent studies have shifted towards using synthetic compounds that mimic antioxidant enzymes, showing promise in treating neurological disorders. Additionally, advancements in "green" extraction processes have enabled the characterization and assessment of bioactive antioxidant compounds from plants. However, there remains a need for more comprehensive investigations to resolve existing controversies and optimize therapeutic strategies.
This research topic aims to explore the role of natural and synthetic antioxidants in the therapeutic targeting of oxidative stress. Specifically, it seeks to answer questions regarding the efficacy of different types of antioxidants, the mechanisms by which they exert their effects, and their potential benefits and drawbacks in treating various diseases. Hypotheses to be tested include the comparative effectiveness of natural versus synthetic antioxidants and the potential for antioxidant enzyme mimetics to offer superior therapeutic outcomes.
To gather further insights into the therapeutic potential of antioxidants, we welcome articles addressing, but not limited to, the following themes:
- Natural and synthetic antioxidants: beneficial and detrimental effects on health
- Therapeutical application of antioxidant enzyme mimetics
- Therapeutic effect of plant extracts
- Dietary antioxidants
- Antioxidant therapeutic strategies
- The role of antioxidants in the prevention of chronic disease
This research topic aims to explore the role of natural and synthetic antioxidants in the therapeutic targeting of oxidative stress. Specifically, it seeks to answer questions regarding the efficacy of different types of antioxidants, the mechanisms by which they exert their effects, and their potential benefits and drawbacks in treating various diseases. Hypotheses to be tested include the comparative effectiveness of natural versus synthetic antioxidants and the potential for antioxidant enzyme mimetics to offer superior therapeutic outcomes.
To gather further insights into the therapeutic potential of antioxidants, we welcome articles addressing, but not limited to, the following themes:
- Natural and synthetic antioxidants: beneficial and detrimental effects on health
- Therapeutical application of antioxidant enzyme mimetics
- Therapeutic effect of plant extracts
- Dietary antioxidants
- Antioxidant therapeutic strategies
- The role of antioxidants in the prevention of chronic disease
Keywords: antioxidants, oxidative stress, ROS, therapeutic strategies, chronic disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
