About this Research Topic
Background: Neurotransmitters are the mediators of synaptic communication between neurons influencing various physiological and behavioral processes, and thus, understanding the mechanisms of their release and corelease is fundamental to understand brain function and plasticity in health and disease. Recent discoveries demystified traditional thinking that neurons release a single neurotransmitter, and characterized neurotransmitter corelease where single neurons release two or more different neurotransmitters or neuromodulators in an increasing number of neuronal population. This emerging area of research promises to uncover novel insights into the complexities of neural communication and its relevance to multiple diseases such as addiction to drugs of abuse.
Goal: The primary objective of this Research Topic is to present novel findings that elucidate the role of neurotransmitter corelease and the underlying mechanisms in diverse neural circuits. We are particularly interested in circuits involved in reward, behavioral reinforcement, and various pathologies related to these neurocircuits, such as addiction. Addiction is a chronic condition characterized by compulsive drug-seeking behavior and a loss of control over substance use. Understanding how neurotransmitter corelease contributes to the circuit function and development of dysfunction in pathology can ultimately lead to new avenues for cutting-edge treatment and interventions strategies.
Our goal is to compile original research articles, comprehensive reviews, and perspectives that spotlight the pivotal role of neurotransmitter corelease in neural functions related to reward, addiction, and a broader spectrum of behavioral processes and disorders. We welcome submissions that investigate the impact of neurotransmitter corelease on neural circuit function, synaptic plasticity, dysfunctional adaptations associated with substance use, addiction susceptibility, and recovery processes.
Scope and Information for Authors: This Research Topic invites contributions focusing on various aspects of neurotransmitter corelease and its implications in health and disease related to reward pathways and functions. Potential areas of interest include, but are not limited to:
• Role of neurotransmitter corelease in the neural circuits involved in goal-directed behaviors, motivation, reward, craving, and reinforcement mechanisms.
• Functional implications of neurotransmitter corelease in addiction, as well as other cognitive and behavioral processes.
• Mechanisms underlying neurotransmitter corelease in addiction and a broader range of neurological and psychiatric conditions.
• Plasticity and adaptations related to neurotransmitter corelease in addiction and other disorders.
• Pharmacological and non-pharmacological interventions targeting neurotransmitter corelease to treat addiction and other related conditions.
• Impact of metabolic hormones on neurotransmitter corelease mechanisms and related behaviors.
• Circadian rhythms and neurotransmitter corelease.
Authors are encouraged to submit original research findings, comprehensive reviews, hypotheses, and theoretical perspectives. We aim to foster a multidisciplinary approach that integrates neurobiology, behavioral neuroscience, pharmacology, and clinical perspectives to advance our understanding of neurotransmitter corelease. By exploring this fascinating area of research, we aspire to pave the way for innovative therapeutic approaches to combat addiction and improve patient outcomes for various neurological and psychiatric conditions.
Goal: The primary objective of this Research Topic is to present novel findings that elucidate the role of neurotransmitter corelease and the underlying mechanisms in diverse neural circuits. We are particularly interested in circuits involved in reward, behavioral reinforcement, and various pathologies related to these neurocircuits, such as addiction. Addiction is a chronic condition characterized by compulsive drug-seeking behavior and a loss of control over substance use. Understanding how neurotransmitter corelease contributes to the circuit function and development of dysfunction in pathology can ultimately lead to new avenues for cutting-edge treatment and interventions strategies.
Our goal is to compile original research articles, comprehensive reviews, and perspectives that spotlight the pivotal role of neurotransmitter corelease in neural functions related to reward, addiction, and a broader spectrum of behavioral processes and disorders. We welcome submissions that investigate the impact of neurotransmitter corelease on neural circuit function, synaptic plasticity, dysfunctional adaptations associated with substance use, addiction susceptibility, and recovery processes.
Scope and Information for Authors: This Research Topic invites contributions focusing on various aspects of neurotransmitter corelease and its implications in health and disease related to reward pathways and functions. Potential areas of interest include, but are not limited to:
• Role of neurotransmitter corelease in the neural circuits involved in goal-directed behaviors, motivation, reward, craving, and reinforcement mechanisms.
• Functional implications of neurotransmitter corelease in addiction, as well as other cognitive and behavioral processes.
• Mechanisms underlying neurotransmitter corelease in addiction and a broader range of neurological and psychiatric conditions.
• Plasticity and adaptations related to neurotransmitter corelease in addiction and other disorders.
• Pharmacological and non-pharmacological interventions targeting neurotransmitter corelease to treat addiction and other related conditions.
• Impact of metabolic hormones on neurotransmitter corelease mechanisms and related behaviors.
• Circadian rhythms and neurotransmitter corelease.
Authors are encouraged to submit original research findings, comprehensive reviews, hypotheses, and theoretical perspectives. We aim to foster a multidisciplinary approach that integrates neurobiology, behavioral neuroscience, pharmacology, and clinical perspectives to advance our understanding of neurotransmitter corelease. By exploring this fascinating area of research, we aspire to pave the way for innovative therapeutic approaches to combat addiction and improve patient outcomes for various neurological and psychiatric conditions.
Keywords: neurotransmitter corelease, neurotransmission, co-transmission, reward, synaptic plasticity, addiction, substance abuse
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
