The emergence and global spread of viral-induced infectious diseases have long been a challenge to public health. Throughout history, these diseases have posed significant threats, with pandemics like COVID-19 serving as stark reminders of the devastating impact such viruses can have on a global scale. The ongoing evolution of viral strains, coupled with factors like increased globalization and urbanization, makes it imperative to develop effective antiviral agents to safeguard public health and global health security.
Recent advances in computational biology and biotechnology have opened up new avenues for identifying and developing antiviral agents In-silico drug design. Combining computational methods and molecular modeling offers a rapid and cost-effective means to screen and design potential antiviral compounds. Additionally, experimental techniques allow for the validation of in-silico predictions, ensuring that identified candidates are both effective and safe.
The relentless emergence and worldwide dissemination of viral-induced infectious diseases have continually presented substantial impediments to public health over time. This specialized endeavor seeks to converge cutting-edge focusing on the conception and refinement of antiviral agents. By targeting viral-induced infectious ailments, this initiative aims to make substantial strides towards fortifying global health security. Specifically, we look for:
• Employment of advanced computational tools and methodologies to screen and design potential antiviral compounds.
• Conducting a comprehensive experimental validation of promising antiviral candidates, including in vitro assays, biophysical studies, and cytotoxicity assessments.
• Enhancing our knowledge of selected compounds' antiviral mechanisms, focusing on their safety and efficacy profiles.
• Generating new insights that can inform the development of effective treatments for life-threatening viral infections, thereby contributing to global health security.
This Research Topic seeks contributions on various aspects of antiviral drug discovery and development, focusing on both in-silico and experimental techniques. Potential topics include, but are not limited to:
1. In-Silico Drug Designing: To identify potential antiviral agents targeting specific viral proteins.
2. Quantitative Structure-Activity Relationship (QSAR)/Pharmacophore Modeling: To predict the activity of antiviral candidates and optimize their chemical structures.
3. Drug Repurposing: Exploration of existing drugs for their potential antiviral effects against different viral infections, with a focus on rapid identification and testing of candidates.
4. Natural Phytochemicals and Food Products: Studies on the potential of natural compounds and food products as immune boosters and antiviral agents against human-infecting viruses.
5. Biophysical and In Vitro Evaluation: Experimental evaluation of identified candidates, including biophysical studies and in vitro assays to assess their antiviral activity and mechanism of action.
6. In Vivo Assessment: Animal model studies to evaluate the efficacy and safety of potent antiviral candidates in minimizing viral load and disease progression
7. Exploring Hypothetical Proteins: Investigations into unidentified (hypothetical) proteins associated with viral infectious diseases, focusing on their potential as novel drug targets
We welcome the following article types: Brief Research Report, Correction, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.
Keywords:
Infectious diseases, In-silico studies, In-vitro assays, In-vivo assays, Biochemical and biophysical characterization, Antiviral drugs development
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The emergence and global spread of viral-induced infectious diseases have long been a challenge to public health. Throughout history, these diseases have posed significant threats, with pandemics like COVID-19 serving as stark reminders of the devastating impact such viruses can have on a global scale. The ongoing evolution of viral strains, coupled with factors like increased globalization and urbanization, makes it imperative to develop effective antiviral agents to safeguard public health and global health security.
Recent advances in computational biology and biotechnology have opened up new avenues for identifying and developing antiviral agents In-silico drug design. Combining computational methods and molecular modeling offers a rapid and cost-effective means to screen and design potential antiviral compounds. Additionally, experimental techniques allow for the validation of in-silico predictions, ensuring that identified candidates are both effective and safe.
The relentless emergence and worldwide dissemination of viral-induced infectious diseases have continually presented substantial impediments to public health over time. This specialized endeavor seeks to converge cutting-edge focusing on the conception and refinement of antiviral agents. By targeting viral-induced infectious ailments, this initiative aims to make substantial strides towards fortifying global health security. Specifically, we look for:
• Employment of advanced computational tools and methodologies to screen and design potential antiviral compounds.
• Conducting a comprehensive experimental validation of promising antiviral candidates, including in vitro assays, biophysical studies, and cytotoxicity assessments.
• Enhancing our knowledge of selected compounds' antiviral mechanisms, focusing on their safety and efficacy profiles.
• Generating new insights that can inform the development of effective treatments for life-threatening viral infections, thereby contributing to global health security.
This Research Topic seeks contributions on various aspects of antiviral drug discovery and development, focusing on both in-silico and experimental techniques. Potential topics include, but are not limited to:
1. In-Silico Drug Designing: To identify potential antiviral agents targeting specific viral proteins.
2. Quantitative Structure-Activity Relationship (QSAR)/Pharmacophore Modeling: To predict the activity of antiviral candidates and optimize their chemical structures.
3. Drug Repurposing: Exploration of existing drugs for their potential antiviral effects against different viral infections, with a focus on rapid identification and testing of candidates.
4. Natural Phytochemicals and Food Products: Studies on the potential of natural compounds and food products as immune boosters and antiviral agents against human-infecting viruses.
5. Biophysical and In Vitro Evaluation: Experimental evaluation of identified candidates, including biophysical studies and in vitro assays to assess their antiviral activity and mechanism of action.
6. In Vivo Assessment: Animal model studies to evaluate the efficacy and safety of potent antiviral candidates in minimizing viral load and disease progression
7. Exploring Hypothetical Proteins: Investigations into unidentified (hypothetical) proteins associated with viral infectious diseases, focusing on their potential as novel drug targets
We welcome the following article types: Brief Research Report, Correction, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.
Keywords:
Infectious diseases, In-silico studies, In-vitro assays, In-vivo assays, Biochemical and biophysical characterization, Antiviral drugs development
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.