Structure and Function of iGluR and their auxiliary subunits

Ionotropic glutamate receptors (iGluRs) are crucial components of the nervous system, mediating rapid excitatory synaptic transmission through their interaction with the non-essential amino acid L-glutamate. These tetrameric receptors are classified into four subtypes, with NMDA, AMPA, and kainate receptors being the most extensively studied. The diversity of iGluRs arises from the combination of different subunits, forming homo and heterotetrametric receptors with distinct biophysical properties. Recent research has highlighted the role of auxiliary subunits in modulating the function and properties of AMPARs and KARs, contributing to the functional diversity of these receptors. Despite the identification of several auxiliary protein families, such as TARPs, GSG1L, and the CKAMP family, the full extent of their regulatory mechanisms remains unclear. While significant progress has been made in characterizing AMPAR and KAR complexes, there is still a need for a deeper understanding of the molecular and structural foundations of iGluR biology, particularly in the context of physiological and pathological conditions.

This research topic aims to advance the understanding of the structure and function of iGluRs and their auxiliary subunits. The primary objectives include elucidating the mechanistic interactions between iGluRs and auxiliary proteins, exploring the functional roles of these auxiliary proteins, and investigating the structural basis of their regulatory effects on iGluRs. By addressing these objectives, the research seeks to fill existing knowledge gaps and provide insights into the complex regulation of glutamatergic signaling.

To gather further insights into the structure and function of iGluRs and their auxiliary subunits, we welcome articles addressing, but not limited to, the following themes:
- Mechanistic work on iGluR-auxiliary protein interactions.
- Extended functional studies of auxiliary proteins modulating iGluRs.
- Structural investigations into how auxiliary subunits regulate iGluRs.
- Exploration of the biosynthesis and regulation of AMPAR and KAR complexes.
- Examination of the role of auxiliary subunits in physiological and pathological conditions.
- Comparative studies of native and recombinant iGluR complexes.