About this Research Topic
Ocular surface disorders encompass a spectrum of pathological conditions ranging from benign to more severe vision threatening conditions affecting the anterior segment of the eye. The prevalence of ocular surface disorders has been increasing due to varied factors like demographic shift to aging population, environmental pollutants and lifestyle habits, invariably impacting the quality of life.
The primary research goal is to elucidate the intricacies of ocular surface disorders at a molecular, cellular, and systemic level. This involves unravelling the etiological factors, deciphering the intricate pathophysiological mechanisms, and advancing our understanding of the complex interplay between genetic predisposition, environmental triggers, and immunological responses with the aim of advancing our understanding and refining clinical management strategies.
The scope of the research encompasses a multidisciplinary approach. Key areas of focus may include:
Aetiology and Risk factors:
Investigating the genetic and epigenetic determinants, environmental factors, and lifestyle influences to understand the underlying cause and risk factors.
Pathophysiology:
Examining the cellular and molecular mechanisms involved in the development and progression of ocular surface disorders, with a focus on inflammatory responses, immune reactions, and tissue remodeling.Assessing the role of the ocular surface microbiome in maintaining homeostasis.
Clinical spectrum :
Highlighting varied clinical presentations and the impact of these disorders on the quality of life.
Diagnostics :
Identifying and validating biomarkers that can aid in the early and accurate diagnosis of ocular surface disorders. Utilizing advanced imaging technologies to precisely characterize structural and functional changes in ocular surface disorders.
Treatment Strategies :
Assessing the efficacy of existing treatments and exploring novel therapeutic options. Exploring regenerative approaches, including stem cell therapies and tissue engineering, for the restoration of ocular surface integrity and function.
The research endeavours to contribute nuanced insights in advancing our understanding of these conditions and paving the way for improved patient care and outcomes.
The primary research goal is to elucidate the intricacies of ocular surface disorders at a molecular, cellular, and systemic level. This involves unravelling the etiological factors, deciphering the intricate pathophysiological mechanisms, and advancing our understanding of the complex interplay between genetic predisposition, environmental triggers, and immunological responses with the aim of advancing our understanding and refining clinical management strategies.
The scope of the research encompasses a multidisciplinary approach. Key areas of focus may include:
Aetiology and Risk factors:
Investigating the genetic and epigenetic determinants, environmental factors, and lifestyle influences to understand the underlying cause and risk factors.
Pathophysiology:
Examining the cellular and molecular mechanisms involved in the development and progression of ocular surface disorders, with a focus on inflammatory responses, immune reactions, and tissue remodeling.Assessing the role of the ocular surface microbiome in maintaining homeostasis.
Clinical spectrum :
Highlighting varied clinical presentations and the impact of these disorders on the quality of life.
Diagnostics :
Identifying and validating biomarkers that can aid in the early and accurate diagnosis of ocular surface disorders. Utilizing advanced imaging technologies to precisely characterize structural and functional changes in ocular surface disorders.
Treatment Strategies :
Assessing the efficacy of existing treatments and exploring novel therapeutic options. Exploring regenerative approaches, including stem cell therapies and tissue engineering, for the restoration of ocular surface integrity and function.
The research endeavours to contribute nuanced insights in advancing our understanding of these conditions and paving the way for improved patient care and outcomes.
Keywords: ocular surface disorders, dry eyes, ocular allergy, chemical injuries, SJS, stem cell transplant, Limbal deficiency
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
