About this Research Topic
We are actively collecting articles that focus on the regulatory functions of polyamines and/or explore the roles of chaperones in protein aggregation, chaperone-client interactions, and proteostasis maintenance. Contributions employing diverse experimental techniques, including genomics, structural biology, proteomics, biochemical tests, and the utilization of animal and cell models, as well as bioinformatics, are highly encouraged. Additionally, we express particular interest in research investigating the intricate interplay among molecular chaperones, polyamines, and other physiological mechanisms such as oxidative stress, inflammation, and immunological responses. Studies that explore new roles of either molecular chaperones or polyamines in various eukaryotic and prokaryotic cells are also encouraged. This inclusive approach will allow for a comprehensive understanding of the impact of these two important biomolecules across diverse biological contexts.
We welcome both research and review articles, covering a broad range of aspects, including but not limited to:
• Description of novel roles of polyamines/molecular chaperones in modulating cellular processes
• Biophysical and biochemical characterization of polyamines/molecular chaperones
• Molecular chaperones/ polyamines in relation to human disease
• Application of molecular chaperones and/or polyamines in the development of novel therapeutics
• Development of molecular chaperone-based biomarkers
Keywords: molecular chaperones, polyamines, protein folding, proteostasis, disease mechanisms, therapeutic targets, diagnostic markers, cellular processes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.