About this Research Topic
Besides favourable effects on cancer-related fatigue, muscular strength, aerobic fitness,and overall quality of life, a growing body of evidence suggests that exercise-induced biological mechanisms play an important role in reducing the risk of cancer progression and recurrence, and improving overall survival. These include increased cancer cell apoptosis, enhancement of tumour-infiltrating lymphocytes, favourable metabolic shifts, reduced metastatic risk and improved treatment responses following chemotherapy, radiotherapy and surgery. Some mechanisms may be cancer-specific. A deeper knowledge of anti-cancer mechanisms driven by exercise, and determining what mode or prescription of exercise is best, would help to understand and harness any therapeutic potential that exercise may have on cancer progression, recurrence and overall survival.
The aim of this Research Topic is to gain new insights into the underlying mechanisms by which exercise may reduce the risk of cancer recurrence, progression and survival, and all-cause mortality.
We welcome original preclinical and clinical research and review articles focused on, but not limited to:
• Systemic adaptive responses to exercise (e.g., inflammatory markers, insulin, growth factors);
• Mitigation of adverse effects of treatment (e.g., fatigue, sarcopenia/cachexia);
• Enhancing the curative effects of treatment;
• Direct effect on tumour (e.g., improved profusion, vascular sheer stress, tumor metabolism, immune response/mobilization and immune cell infiltration of tumors)
The aim of this Research Topic is to gain new insights into the underlying mechanisms by which exercise may reduce the risk of cancer recurrence, progression and survival, and all-cause mortality.
We welcome original preclinical and clinical research and review articles focused on, but not limited to:
• Systemic adaptive responses to exercise (e.g., inflammatory markers, insulin, growth factors);
• Mitigation of adverse effects of treatment (e.g., fatigue, sarcopenia/cachexia);
• Enhancing the curative effects of treatment;
• Direct effect on tumour (e.g., improved profusion, vascular sheer stress, tumor metabolism, immune response/mobilization and immune cell infiltration of tumors)
Keywords: Cancer, Exercise, Mortality, Morbidity, Physical Activity, Progression, Recurrence, Survival, Mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
