Genetics and Mechanisms of Neurodevelopmental Disorders

Neurodevelopmental disorders and their comorbidities represent a complex group of conditions that affect the proper development and functioning of the nervous system. These disorders tend to have a heterogeneous genetic etiology and marked clinical variability, exerting a substantial burden on society. Despite significant advancements in identifying the genetic components of these diseases over the last decade, many individuals still do not receive a definitive diagnosis. Even for those who do, optimal treatment and management options remain elusive due to insufficient insights into the mechanisms of disease. Therefore, understanding the phenotypic, genetic, and mechanistic underpinnings of these disorders is crucial for developing targeted interventions and improving the lives of affected individuals.

This Research Topic aims to explore the genetic abnormalities and mechanisms underlying neurodevelopmental disorders and provide insights into their diagnosis, management, and treatment. By bringing together multidisciplinary research, we aim to capture the application of new technology and methods for the diagnosis of neurodevelopmental disorders, atypical presentations of disease or phenotypic expansion, and insights into the mechanisms of disease and altered molecular pathways.

To gather further insights into the genetic and mechanistic aspects of neurodevelopmental disorders, we welcome articles addressing, but not limited to, the following themes:
- Atypical presentation of known genetic disorders or phenotypic expansion of disease.
- Identification and characterization of genetic abnormalities related to neurodevelopmental disorders through new technology and/or technology improvements.
- Investigation of underlying molecular and cellular mechanisms impacting brain development and function.
- Animal models and experimental approaches to studying neurodevelopmental disorders.
- Biomarkers and diagnostic tools for early identification and intervention.
- Therapeutic strategies and interventions targeting specific molecular pathways.

We invite original research articles, case reports, reviews, perspectives, and clinical studies that provide valuable insights into the field of genetics and mechanisms of neurodevelopmental disorders. Manuscripts must adhere to the guidelines provided by the journal for formatting and submission

Keywords: Genetic Abnormalities, Neurodevelopmental Disorders, Autism Spectrum Disorder

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.