About this Research Topic
Cellular and molecular regulators play a pivotal role in non-neoplastic immune-mediated diseases, where the immune system mistakenly targets healthy cells and tissues. These diseases encompass a diverse range, including autoimmune disorders and inflammatory conditions. The intricate interplay of cellular elements, such as T and B lymphocytes, macrophages, and dendritic cells, is regulated by molecular signals like cytokines and chemokines. Dysregulation in these intricate networks leads to an aberrant immune response, resulting in tissue damage and chronic inflammation. Understanding the cellular and molecular regulators is crucial for unraveling the pathogenesis of these diseases and developing targeted therapeutic interventions. Advances in immunology have shed light on key signaling pathways, immune checkpoints, and genetic factors that influence disease susceptibility, paving the way for innovative treatments and personalized medicine approaches in the realm of non-neoplastic immune-mediated diseases, such as rheumatic, skin, and oral disorders.
The overarching goal of this Research Topic is to decipher the intricate mechanisms underlying these disorders, aiming to pave the way for more targeted and effective therapeutic interventions. The problem at hand lies in the complex and often elusive nature of these diseases, where the immune system mistakenly attacks the body's own tissues, leading to chronic inflammation and tissue damage. To address this challenge, researchers strive to unravel the specific cellular and molecular triggers that initiate and perpetuate the immune response in conditions like rheumatoid arthritis, glomerulonephritis, psoriasis, pemphigus, lichen planus, and inflammatory bowel diseases. Innovative technologies, such as single-cell genomics and advanced imaging techniques, offer unprecedented insights into the heterogeneity of immune cells and their interactions within tissues. Additionally, the identification of novel therapeutic targets, including cytokines and immune modulators, holds promise for the development of precision medicine approaches tailored to individual patients. By elucidating the regulatory mechanisms governing non-neoplastic immune-mediated diseases, studies aim to transform our understanding of these conditions and ultimately improve patient outcomes through the development of more targeted and personalized treatment strategies.
This Research Topic seeks to explore the intricate cellular and molecular regulators in non-neoplastic immune-mediated diseases, encompassing autoimmune disorders and inflammatory conditions. We encourage contributors to delve into themes such as the identification of key immune cell subsets, signaling pathways, and genetic factors influencing disease pathogenesis. Manuscripts that elucidate the role of cytokines, chemokines, and immune checkpoints, as well as those exploring novel therapeutic targets, are particularly welcomed. We aim to foster a comprehensive understanding of these diseases, emphasizing recent advances in technologies such as single-cell genomics and imaging techniques. We invite original research articles, reviews, meta-analyses, and case reports that contribute to unraveling the complexity of non-neoplastic immune-mediated diseases. By bringing together diverse perspectives, we aim to advance our knowledge and pave the way for innovative and personalized approaches to diagnosis and treatment in this challenging medical landscape.
The overarching goal of this Research Topic is to decipher the intricate mechanisms underlying these disorders, aiming to pave the way for more targeted and effective therapeutic interventions. The problem at hand lies in the complex and often elusive nature of these diseases, where the immune system mistakenly attacks the body's own tissues, leading to chronic inflammation and tissue damage. To address this challenge, researchers strive to unravel the specific cellular and molecular triggers that initiate and perpetuate the immune response in conditions like rheumatoid arthritis, glomerulonephritis, psoriasis, pemphigus, lichen planus, and inflammatory bowel diseases. Innovative technologies, such as single-cell genomics and advanced imaging techniques, offer unprecedented insights into the heterogeneity of immune cells and their interactions within tissues. Additionally, the identification of novel therapeutic targets, including cytokines and immune modulators, holds promise for the development of precision medicine approaches tailored to individual patients. By elucidating the regulatory mechanisms governing non-neoplastic immune-mediated diseases, studies aim to transform our understanding of these conditions and ultimately improve patient outcomes through the development of more targeted and personalized treatment strategies.
This Research Topic seeks to explore the intricate cellular and molecular regulators in non-neoplastic immune-mediated diseases, encompassing autoimmune disorders and inflammatory conditions. We encourage contributors to delve into themes such as the identification of key immune cell subsets, signaling pathways, and genetic factors influencing disease pathogenesis. Manuscripts that elucidate the role of cytokines, chemokines, and immune checkpoints, as well as those exploring novel therapeutic targets, are particularly welcomed. We aim to foster a comprehensive understanding of these diseases, emphasizing recent advances in technologies such as single-cell genomics and imaging techniques. We invite original research articles, reviews, meta-analyses, and case reports that contribute to unraveling the complexity of non-neoplastic immune-mediated diseases. By bringing together diverse perspectives, we aim to advance our knowledge and pave the way for innovative and personalized approaches to diagnosis and treatment in this challenging medical landscape.
Keywords: Rheumatoid arthritis, Glomerulonephritis, Lichen planus, Pemphigus, Psoriasis, Inflammatory bowel diseases, Autoimmune disorders, Inflammatory conditions, Cellular regulators, Molecular signaling pathways, Immune-mediated diseases, Cytokines, Chemokines, Genetic factors, Therapeutic targets, Precision medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
