Glycolipid Metabolism Disorders in Cerebrovascular and Cardiovascular Diseases: Advanced Insights Into Pathology, Pathophysiology and Treatment

Cardiovascular and cerebrovascular diseases have emerged major causes of morbidity and are implicated in the majority of sudden cardiac deaths worldwide: with an estimated annual mortality of approximately 17.9 million individuals succumbing to cardiovascular disease, comprising one-third of total mortality rates. Although the immune system activation and inflammatory response serve as the primary pathological basis for these diseases, recent evidence has elucidated a multitude of mechanisms - including hyperlipidemia, insulin resistance, and hemodynamic alterations - that synergistically contribute to disease progression. Glycolipid metabolism is a vital cellular and systemic process for energy and material provision, while its homeostasis plays a crucial role in adapting to the dynamic changes of internal and external environments. Despite considerable attention given by researchers to the impact of glycolipid metabolism disorders on cardiovascular and cerebrovascular diseases, the precise pathological alterations and underlying mechanisms remain elusive.

Significant progress has been made in the study of glycolipid metabolism disorders in cardiovascular and cerebrovascular diseases, due to rapid advancements in the fields of multi-omics, gene editing, single-cell analysis, and single-molecule science and technology. This development involves a shift from molecular-level investigations to network interaction integration, as well as static to dynamic and environmental interaction analyses. Concurrently, there is a deepening integration of basic research with healthy lifestyle guidance, new drug research and development, and clinical disease diagnosis and treatment. The objectives of this research project encompass the pathological and pathophysiological effects of glycolipid metabolism disorders in cardiovascular and cerebrovascular diseases, as well as the potential roles of novel therapeutic agents and therapies.

This Research Topic aims to focus on the most recent advancements in the field, calls for submissions of Original Research, Reviews, Case studies, and Methods, as listed but not limited to the following:

• The influence of glycolipid metabolism disorders on vascular pathology
• The impact of pathophysiological mechanisms related to glycolipid metabolism on cardiovascular and cerebrovascular diseases
• The effects of carbohydrate-lipid metabolism-related products, including lipids, sugars, and other silver, on cardiovascular and cerebrovascular diseases
• Therapeutics targeting glycolipid metabolism disorders in cardiovascular and cerebrovascular diseases