About this Research Topic
This Research Topic aims to unravel the intricate dynamics of host-pathogen interactions in bacterial infections, leveraging insights from omics and machine learning technologies. Specifically, we seek to identify and characterize bacterial virulence factors and host immune proteins critical for infection outcomes; pinpoint pivotal biomarkers and signaling cascades driving pathogenic processes, facilitating the discovery of novel therapeutic targets; and translate research findings into clinically relevant insights and diagnostic tools to develop precision medicine approaches tailored to individual patients and specific bacterial infections. By achieving these objectives, we endeavor to advance the understanding of the molecular mechanisms driving bacterial pathogenesis and host immune responses as well as contribute to the development of innovative strategies for disease management and intervention.
We seek Original Research articles, Reviews, Brief Research Reports, and Mini Reviews that cover, but are not limited to, the following topics:
1. Exploration of underlying mechanisms of bacterial pathogenesis and host immune response by integrating multi-omics data (genomics, transcriptomics, proteomics, metabolomics, microbiomics).
2. Development of computational algorithms and tools for identifying bacterial virulence factors and their interactions with host proteins using machine learning approaches.
3. Development of predictive frameworks for forecasting infection severity, disease progression, and treatment responses.
4. Identification of host factors and pathways contributing to immune response using omics approaches.
5. Identification of biomarkers by interacting omics and machine learning approaches.
Keywords: Host-Pathogen Interaction, Pathogenesis, Immune Response, Omics, Machine Learning
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.