About this Research Topic
commonly disturbed in neurodegenerative diseases yet are typically neglected in clinical practice. However, many distinct pathophysiological abnormalities appear in the eye in response to endocrinopathies and govern the dynamics of neurodegenerative diseases, but their mechanisms are still unknown. In this regard, the eye can help physicians identify and manage a wide range of systemic diseases, including several endocrine problems associated with neurodegeneration. Recognizing ocular signs of neuroendocrine abnormalities is crucial not only for early detection and treatment, but also for avoiding severe morbidity and mortality associated with these disorders.
A wide variety of ocular abnormalities have been observed in people with hereditary neurodegenerative diseases. These disorders, particularly those affecting the optic nerve and retina, can result in significant loss of visual function. Besides, these neurodegenerative disorders have specific eye movement anomalies, which can aid in understanding brain disease mechanisms and the motion visual system. Identification of these associations is an important step toward diagnosing and managing these complex aetiologies. It can aid in finding the clinical features of neurodegeneration in a variety of aging illness, including but not limited to Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, muscular dystrophies, ataxias, spastic paraplegia, and glioblastoma. The purpose
of this research topic is to highlight the neuro-ophthalmic disease processes associated with endocrinological dysfunction.
This topic seeks to collect research from pertinent neuro-ocular abnormalities, disease markers and mechanisms associated with endocrine system dysfunction. These include hypothalamic-pituitary axis, thyroid, and pancreas in neurodegenerative disorders. The purpose of this Research Topic is to highlight neuro-ophthalmic disease processes that have implications for endocrine function, employing different research techniques. We welcome the submissionof original research, meta-analysis or bioinformatic study, review, mini review, perspective, and opinion articles that address but are not limited to:
1. Diverse afferent visual systems and other ocular characteristics such as inflammation and other neural regulators of neurodegeneration.
2. Role of retinal imaging and Ophthalmic findings as biomarkers of disease severity.
3. Synergistic mechanisms between endocrine system dysfunction and neurodegeneration.
4. Gut-brain axis in endocrine system dysfunction and degenerative eyes.
5. Molecular crosstalk between overlapping aetiological phenotypes among endocrine system and degenerative brain and eyes.
6. Recent therapeutic perspectives and implementation of artificial intelligence and machine learning approaches for early diagnoses and detection of neurodegeneration in endocrine system dysfunctions.
Keywords: Neurodegeneration, Endocrine System, Ophthalmic manifestations, Diagnosis, Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.