Structural Dynamics of Dementia and Depression: A Diffusion MRI Study

Dementia and depression are distinct yet frequently concurrent conditions that profoundly affect an individual's cognitive and emotional well-being. Dementia involves symptoms that impair memory, thinking, and social skills, hindering daily functioning. Conversely, depression is characterized by persistent feelings of sadness, hopelessness, and disinterest in activities. Their coexistence presents unique challenges in diagnosis, treatment, and management. Advanced diffusion MRI techniques provide valuable insights into the neural complexities of dementia and depression. These methods allow researchers to examine the microstructural integrity of white matter tracts, detect subtle changes in neural connectivity, and understand the interaction between structural alterations in dementia and neural aspects of depression. Despite significant advancements, there remains a gap in understanding the neural interplay between these conditions, necessitating further investigation to improve diagnostic and therapeutic strategies.

This Research Topic aims to investigate the neural intricacies of comorbid dementia and depression using advanced MRI techniques. By uncovering the structural dynamics and interplay between these conditions, the goal is to enhance diagnostics and interventions for individuals facing this complex intersection of mental health disorders. Specifically, the research will focus on identifying subtle alterations in neural connectivity and elucidating the interaction between structural changes observed in dementia and the neural correlates of depression.

To gather further insights into the neurobiological overlap between dementia and depression, we welcome articles addressing, but not limited to, the following themes:
- Examining White Matter Integrity in Late-Life Depression and Dementia
- Exploring Early Cognitive Decline Detection in Depression Through Diffusion MRI
- Examining dMRI’s Role in Monitoring Treatment Response for Depression and Dementia
- Advanced dMRI Connectomics Studies Investigating Structural Brain Networks in Individuals with Depression and Dementia
- Exploring Neuroinflammation and White Matter Changes in Individuals Affected by Depression and Dementia
- Longitudinal Investigation of White Matter Changes in Individuals with Depression and Dementia
- Exploring the Impact of Genetics and Environment on White Matter Integrity
- Investigating Cerebellar Involvement in Individuals with Dementia and Depression Using dMRI

Keywords: Diffusion MRI (dMRI), Dementia, Diffusion tensor imaging (DTI), Depression, Magnetic Resonance Imaging (MRI), Alzheimer's

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.