About this Research Topic
This research topic aims to explore and address the challenges associated with CNS disease-targeted drug discovery, particularly focusing on the development and application of TPD strategies. The primary objectives include investigating the degradation pathways of CNS disease-causing proteins, enhancing the understanding of BBB models for drug delivery, and advancing CNS disease cell and organoid models. By addressing these areas, the research seeks to expand the repertoire of therapeutic degraders and improve the efficacy of CNS disease-targeted treatments.
To gather further insights in the realm of CNS disease-targeted drug discovery, we welcome articles addressing, but not limited to, the following themes:
- Development and application of CNS disease cell and organoid models.
- Exploration of degradation pathways for CNS disease-causing proteins.
- Innovations in blood-brain barrier models for enhanced drug delivery.
- Advances in CNS disease-targeted drug discovery, including TPD degraders and protein functional inhibitors.
Keywords: posttranslational modifications, UB, SUMO
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.